Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00215"

Predicate	Value (sorted: default)
rdfs:label	"Citalopram"
rdf:type	drugbank:drugs
drugbank:description	"Citalopram hydrobromide belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Citalopram and its N-demethylated metabolites exist as a racemic mixture but its effects are largely due to the S-enantiomer, S-citalopram and S-demthylcitalopram. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize &alpha;- or &beta;-adrenergic, dopamine D<sub>2</sub> or histamine H<sub>1</sub> receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Citalopram is approved for treatment of depression. Unlabeled indications include mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy. Citalopram has the fewest drug-drug interactions of the SSRIs. "
drugbank:drugCategory	drugcategory:Antidepressive Agents drugcategory:Antidepressive Agents, Second-Generation drugcategory:Serotonin Uptake Inhibitors
drugbank:interactsWith	drug:Tramadol drug:Erythromycin drug:Ticlopidine drug:Eletriptan drug:Ziprasidone drug:Metoprolol drug:Dicoumarol drug:Venlafaxine drug:Zolmitriptan drug:Clozapine drug:Treprostinil drug:Triprolidine drug:Oxycodone drug:Tolmetin drug:Propranolol drug:Voriconazole drug:Linezolid drug:Trazodone drug:Sumatriptan drug:Warfarin drug:Trimipramine drug:Tranylcypromine drug:Phenelzine drug:Almotriptan drug:Naratriptan drug:Rizatriptan drug:Telithromycin drug:Frovatriptan drug:Ketoprofen drug:Selegiline drug:Pimozide drug:Sibutramine drug:Anisindione drug:Carvedilol drug:Moclobemide drug:Clarithromycin drug:Isocarboxazid drug:Josamycin drug:St. John's Wort drug:Troleandomycin drug:Rasagiline drug:Ginkgo biloba drug:Acenocoumarol drug:Tiaprofenic acid drug:Zuclopenthixol drug:Etravirine drug:Artemether drug:Desvenlafaxine drug:Lumefantrine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate
owl:sameAs	drug:APRD00147 drug:BE0002363 drug:BE0002638 drug:BE0003536 drug:Tramadol drug:Erythromycin drug:Ticlopidine drug:Citalopram drug:Eletriptan drug:Ziprasidone drug:Metoprolol drug:Dicoumarol drug:Venlafaxine drug:Zolmitriptan drug:Clozapine drug:Treprostinil drug:Triprolidine drug:Oxycodone drug:Tolmetin drug:Propranolol drug:Voriconazole drug:Linezolid drug:Trazodone drug:Sumatriptan drug:Warfarin drug:Trimipramine drug:Tranylcypromine drug:Phenelzine drug:Almotriptan drug:Naratriptan drug:Rizatriptan drug:Telithromycin drug:Frovatriptan drug:Ketoprofen drug:Selegiline drug:Pimozide drug:Sibutramine drug:Anisindione drug:Carvedilol drug:Moclobemide drug:Clarithromycin drug:Isocarboxazid drug:Josamycin drug:St. John's Wort drug:Troleandomycin drug:Rasagiline drug:Ginkgo biloba drug:Acenocoumarol drug:Tiaprofenic acid drug:Zuclopenthixol drug:Etravirine drug:Artemether drug:Desvenlafaxine drug:Lumefantrine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate drug:DBMET00195 drug:DBMET00196 drug:DBMET00659 drug:DBMET00661 drug:DBSALT000027

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt

The resource appears as object in 103 triples

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