Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00264"

Predicate	Value (sorted: default)
rdfs:label	"Metoprolol"
rdf:type	drugbank:drugs
drugbank:description	"Metoprolol is a cardioselective β1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the <i>para</i> position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the <i>para</i> position. At low doses, metoprolol selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with higher doses. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for β-adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture. "
drugbank:drugCategory	drugcategory:Adrenergic beta-1 Receptor Antagonists drugcategory:Anti-Arrhythmia Agents drugcategory:Antihypertensive Agents drugcategory:Sympatholytics
drugbank:interactsWith	drug:Insulin Glargine drug:Citalopram drug:Pipobroman drug:Methysergide drug:Disopyramide drug:Lidocaine drug:Dihydroergotamine drug:Indomethacin drug:Diltiazem drug:Treprostinil drug:Acetohexamide drug:Prazosin drug:Fluoxetine drug:Cimetidine drug:Piroxicam drug:Clonidine drug:Verapamil drug:Epinephrine drug:Chlorpropamide drug:Ergotamine drug:Paroxetine drug:Primidone drug:Orciprenaline drug:Tolazamide drug:Terbinafine drug:Terbutaline drug:Repaglinide drug:Salmeterol drug:Telithromycin drug:Formoterol drug:Salbutamol drug:Glyburide drug:Rifampicin drug:Ibuprofen drug:Isoprenaline drug:Glipizide drug:Sertraline drug:Gliclazide drug:Tolbutamide drug:Terazosin drug:Phenobarbital drug:Escitalopram drug:Propafenone drug:Ergonovine drug:Hydralazine drug:Fenoterol drug:Glisoxepide drug:Pirbuterol drug:Procaterol drug:Glycodiazine drug:Dronedarone drug:Mirabegron
owl:sameAs	drug:APRD00208 drug:BE0002363 drug:Insulin Glargine drug:Citalopram drug:Pipobroman drug:Methysergide drug:Metoprolol drug:Disopyramide drug:Lidocaine drug:Dihydroergotamine drug:Indomethacin drug:Diltiazem drug:Treprostinil drug:Acetohexamide drug:Prazosin drug:Fluoxetine drug:Cimetidine drug:Piroxicam drug:Clonidine drug:Verapamil drug:Epinephrine drug:Chlorpropamide drug:Ergotamine drug:Paroxetine drug:Primidone drug:Orciprenaline drug:Tolazamide drug:Terbinafine drug:Terbutaline drug:Repaglinide drug:Salmeterol drug:Telithromycin drug:Formoterol drug:Salbutamol drug:Glyburide drug:Rifampicin drug:Ibuprofen drug:Isoprenaline drug:Glipizide drug:Sertraline drug:Gliclazide drug:Tolbutamide drug:Terazosin drug:Phenobarbital drug:Escitalopram drug:Propafenone drug:Ergonovine drug:Hydralazine drug:Fenoterol drug:Glisoxepide drug:Pirbuterol drug:Procaterol drug:Glycodiazine drug:Dronedarone drug:Mirabegron drug:DBMET00319 drug:DBSALT000862 drug:DBSALT000863

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt

The resource appears as object in 105 triples

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