Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00344"

Predicate	Value (sorted: default)
rdfs:label	"Protriptyline"
rdf:type	drugbank:drugs
drugbank:description	"Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression. "
drugbank:drugCategory	drugcategory:Adrenergic Uptake Inhibitors drugcategory:Antidepressive Agents, Tricyclic
drugbank:interactsWith	drug:Fluvoxamine drug:Tramadol drug:Trospium drug:Butabarbital drug:Butalbital drug:Ziprasidone drug:Venlafaxine drug:Zolmitriptan drug:Terfenadine drug:Grepafloxacin drug:Tacrine drug:Phenylephrine drug:Phenylpropanolamine drug:Triprolidine drug:Fluoxetine drug:Cimetidine drug:Toremifene drug:Clonidine drug:Voriconazole drug:Cisapride drug:Rifabutin drug:Trazodone drug:Trimethobenzamide drug:Epinephrine drug:Galantamine drug:Trimipramine drug:Tranylcypromine drug:Phenelzine drug:Orciprenaline drug:Donepezil drug:Pseudoephedrine drug:Terbinafine drug:Tacrolimus drug:Terbutaline drug:Quinidine drug:Rifampicin drug:Atazanavir drug:Guanethidine drug:Moclobemide drug:Isocarboxazid drug:Fenoterol drug:Rasagiline drug:Thiothixene drug:Zuclopenthixol drug:Vorinostat drug:Artemether drug:Desvenlafaxine drug:Lumefantrine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate
owl:sameAs	drug:APRD00441 drug:Fluvoxamine drug:Tramadol drug:Trospium drug:Butabarbital drug:Butalbital drug:Ziprasidone drug:Venlafaxine drug:Zolmitriptan drug:Terfenadine drug:Grepafloxacin drug:Tacrine drug:Phenylephrine drug:Phenylpropanolamine drug:Triprolidine drug:Fluoxetine drug:Cimetidine drug:Toremifene drug:Clonidine drug:Voriconazole drug:Cisapride drug:Rifabutin drug:Trazodone drug:Trimethobenzamide drug:Epinephrine drug:Galantamine drug:Trimipramine drug:Tranylcypromine drug:Phenelzine drug:Orciprenaline drug:Donepezil drug:Pseudoephedrine drug:Terbinafine drug:Tacrolimus drug:Terbutaline drug:Quinidine drug:Rifampicin drug:Atazanavir drug:Guanethidine drug:Moclobemide drug:Isocarboxazid drug:Fenoterol drug:Rasagiline drug:Thiothixene drug:Zuclopenthixol drug:Vorinostat drug:Artemether drug:Desvenlafaxine drug:Lumefantrine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt

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