Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00381"

PredicateValue (sorted: default)
rdfs:label
"Amlodipine"
rdf:type
drugbank:drugs
drugbank:description
"Amlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Some studies have shown that amlodipine also exerts inhibitory effects on voltage-gated N-type calcium channels. N-type calcium channels located in the central nervous system may be involved in nociceptive signaling and pain sensation. Amlodipine is used to treat hypertension and chronic stable angina. "
drugbank:drugCategory
drugcategory:Antianginal Agents
drugcategory:Antihypertensive Agents
drugcategory:Calcium Channel Blockers
drugcategory:Vasodilator Agents
drugbank:interactsWith
drug:Diltiazem
drug:Treprostinil
drug:Tacrine
drug:Voriconazole
drug:Thiopental
drug:Tizanidine
drug:Tipranavir
drug:Telithromycin
drug:Quinupristin
drug:Telaprevir
owl:sameAs
drug:APRD00520
drug:Diltiazem
drug:Treprostinil
drug:Tacrine
drug:Voriconazole
drug:Thiopental
drug:Tizanidine
drug:Tipranavir
drug:Telithromycin
drug:Quinupristin
drug:Telaprevir
drug:DBSALT001054
drug:DBSALT001055
drug:DBSALT001056

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt

The resource appears as object in 20 triples

Context graph