Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00744"

PredicateValue (sorted: default)
rdfs:label
"Zileuton"
rdf:type
drugbank:drugs
drugbank:description
"Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid. Specifically, it inhibits leukotriene LTB4, LTC4, LTD4, and LTE4 formation. Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. The immediate release tablet of Zileuton has been withdrawn from the US market. "
drugbank:drugCategory
drugcategory:Anti-Inflammatory Agents, Non-Steroidal
drugcategory:Leukotriene Antagonists
drugcategory:Lipoxygenase Inhibitors
drugbank:interactsWith
drug:Theophylline
drug:Dihydroergotamine
drug:Ergotamine
drug:Ramelteon
drug:Pimozide
drug:Aminophylline
drug:Oxtriphylline
drug:Eltrombopag
drug:DB06769
owl:sameAs
drug:APRD00265
drug:BE0000017
drug:BE0002433
drug:BE0002638
drug:BE0002793
drug:BE0003538
drug:Theophylline
drug:Dihydroergotamine
drug:Ergotamine
drug:Zileuton
drug:Ramelteon
drug:Pimozide
drug:Aminophylline
drug:Oxtriphylline
drug:Eltrombopag
drug:DB06769
drug:DBMET00138
drug:DBMET00139
drug:DBMET00140
drug:DBMET00141
drug:DBMET01255

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt

The resource appears as object in 18 triples

Context graph