Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01016"

Predicate	Value (sorted: default)
rdfs:label	"Glyburide"
rdf:type	drugbank:drugs
drugbank:description	"Glyburide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating &beta; cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic &beta; cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Glyburide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Glyburide appears to be completely metabolized, likely in the liver. Although its metabolites exert a small hypoglycemic effect, their contribution to glyburide's hypoglycemic effect is thought to be clinically unimportant. Glyburide metabolites are excreted in urine and feces in approximately equal proportions. The half-life of glyburide appears to be unaffected in those with a creatinine clearance of greater than 29 ml/min/1.73m<sup>2</sup>. "
drugbank:drugCategory	drugcategory:Anti-Arrhythmia Agents drugcategory:Antidiabetic Agents drugcategory:Hypoglycemic Agents
drugbank:interactsWith	drug:Somatropin recombinant drug:Cyclosporine drug:Esmolol drug:Betaxolol drug:Metoprolol drug:Dicoumarol drug:Atenolol drug:Timolol drug:Chloramphenicol drug:Sotalol drug:Carteolol drug:Bosentan drug:Propranolol drug:Labetalol drug:Bisoprolol drug:Clofibrate drug:Phenylbutazone drug:Colesevelam drug:Acetylsalicylic acid drug:Pindolol drug:Rifampicin drug:Diazoxide drug:Carvedilol drug:Acebutolol drug:Nadolol drug:Bismuth Subsalicylate drug:Bevantolol drug:Glucosamine drug:Practolol drug:Penbutolol drug:Magnesium salicylate drug:Salicylate-sodium drug:Salsalate drug:Trisalicylate-choline drug:Oxprenolol
owl:sameAs	drug:APRD00233 drug:BE0002638 drug:BE0002793 drug:BE0003536 drug:Somatropin recombinant drug:Cyclosporine drug:Esmolol drug:Betaxolol drug:Metoprolol drug:Dicoumarol drug:Atenolol drug:Timolol drug:Chloramphenicol drug:Sotalol drug:Carteolol drug:Bosentan drug:Propranolol drug:Labetalol drug:Bisoprolol drug:Clofibrate drug:Phenylbutazone drug:Colesevelam drug:Acetylsalicylic acid drug:Pindolol drug:Glyburide drug:Rifampicin drug:Diazoxide drug:Carvedilol drug:Acebutolol drug:Nadolol drug:Bismuth Subsalicylate drug:Bevantolol drug:Glucosamine drug:Practolol drug:Potassium drug:Penbutolol drug:Calcium drug:Magnesium salicylate drug:Salicylate-sodium drug:Salsalate drug:Trisalicylate-choline drug:Oxprenolol drug:DBMET00207 drug:DBMET00208 drug:DBMET00209 drug:DBMET00210 drug:DBMET00211

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt

The resource appears as object in 73 triples

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