Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01104"

Predicate	Value (sorted: default)
rdfs:label	"Sertraline"
rdf:type	drugbank:drugs
drugbank:description	"Sertraline hydrochloride belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize &alpha;- or &beta;-adrenergic, dopamine D<sub>2</sub> or histamine H<sub>1</sub> receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache (see Toxicity section below for a more detailed listing of side effects). Compared to other agents in this class, sertraline may cause greater diarrheal and male sexual dysfunction effects. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Sertraline may be used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and social anxiety disorder (social phobia). "
drugbank:drugCategory	drugcategory:Antidepressive Agents drugcategory:Serotonin Uptake Inhibitors
drugbank:interactsWith	drug:Tramadol drug:Erythromycin drug:Eletriptan drug:Phenytoin drug:Metoprolol drug:Venlafaxine drug:Zolmitriptan drug:Clozapine drug:Treprostinil drug:Triprolidine drug:Oxycodone drug:Tolmetin drug:Carbamazepine drug:Propranolol drug:Linezolid drug:Trazodone drug:Galantamine drug:Tamoxifen drug:Tamsulosin drug:Trimipramine drug:Tranylcypromine drug:Phenelzine drug:Donepezil drug:Terbinafine drug:Almotriptan drug:Tipranavir drug:Naratriptan drug:Frovatriptan drug:Ketoprofen drug:Tolterodine drug:Pimozide drug:Carvedilol drug:Cilostazol drug:Moclobemide drug:Propafenone drug:Clarithromycin drug:Isocarboxazid drug:Fosphenytoin drug:Rasagiline drug:Ginkgo biloba drug:Tiaprofenic acid drug:Desvenlafaxine
owl:sameAs	drug:APRD00175 drug:BE0002638 drug:Tramadol drug:Erythromycin drug:Eletriptan drug:Phenytoin drug:Metoprolol drug:Venlafaxine drug:Zolmitriptan drug:Clozapine drug:Treprostinil drug:Triprolidine drug:Oxycodone drug:Tolmetin drug:Carbamazepine drug:Propranolol drug:Linezolid drug:Trazodone drug:Galantamine drug:Tamoxifen drug:Tamsulosin drug:Trimipramine drug:Tranylcypromine drug:Phenelzine drug:Donepezil drug:Terbinafine drug:Almotriptan drug:Tipranavir drug:Naratriptan drug:Frovatriptan drug:Ketoprofen drug:Tolterodine drug:Pimozide drug:Sertraline drug:Carvedilol drug:Cilostazol drug:Moclobemide drug:Propafenone drug:Clarithromycin drug:Isocarboxazid drug:Fosphenytoin drug:Rasagiline drug:Ginkgo biloba drug:Tiaprofenic acid drug:Desvenlafaxine drug:DBMET00335 drug:DBSALT000808

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The resource appears as object in 85 triples

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