Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01124"

Predicate	Value (sorted: default)
rdfs:label	"Tolbutamide"
rdf:type	drugbank:drugs
drugbank:description	"Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Tolbutamide appears to be metabolized in the liver. Tolbutamide and its metabolites are excreted in urine (75-85%) and feces. "
drugbank:drugCategory	drugcategory:Antidiabetic Agents drugcategory:Hypoglycemic Agents
drugbank:interactsWith	drug:Somatropin recombinant drug:Esmolol drug:Fluconazole drug:Torasemide drug:Glimepiride drug:Dapsone drug:Phenytoin drug:Sulfisoxazole drug:Metoprolol drug:Floxuridine drug:Indomethacin drug:Atenolol drug:Sulfadiazine drug:Timolol drug:Digoxin drug:Trimethoprim drug:Chloramphenicol drug:Montelukast drug:Fluoxetine drug:Celecoxib drug:Fluorouracil drug:Zafirlukast drug:Piroxicam drug:Bosentan drug:Propranolol drug:Voriconazole drug:Labetalol drug:Bisoprolol drug:Nicardipine drug:Clofibrate drug:Tamoxifen drug:Losartan drug:Warfarin drug:Delavirdine drug:Flurbiprofen drug:Nateglinide drug:Mefenamic acid drug:Phenylbutazone drug:Acetylsalicylic acid drug:Pindolol drug:Sulfamethoxazole drug:Ketoconazole drug:Rifampicin drug:Ibuprofen drug:Glipizide drug:Capecitabine drug:Miconazole drug:Carvedilol drug:Sulfinpyrazone drug:Acebutolol drug:Zopiclone drug:Nadolol drug:Ketamine drug:Paclitaxel drug:Gemfibrozil drug:Lumiracoxib drug:Fosphenytoin drug:Mestranol drug:Acenocoumarol drug:Oxprenolol drug:Sitaxentan
owl:sameAs	drug:APRD00267 drug:BE0002793 drug:BE0003536 drug:Somatropin recombinant drug:Esmolol drug:Fluconazole drug:Torasemide drug:Glimepiride drug:Dapsone drug:Phenytoin drug:Sulfisoxazole drug:Metoprolol drug:Floxuridine drug:Indomethacin drug:Atenolol drug:Sulfadiazine drug:Timolol drug:Digoxin drug:Trimethoprim drug:Chloramphenicol drug:Montelukast drug:Fluoxetine drug:Celecoxib drug:Fluorouracil drug:Zafirlukast drug:Piroxicam drug:Bosentan drug:Propranolol drug:Voriconazole drug:Labetalol drug:Bisoprolol drug:Nicardipine drug:Clofibrate drug:Tamoxifen drug:Losartan drug:Warfarin drug:Delavirdine drug:Flurbiprofen drug:Nateglinide drug:Mefenamic acid drug:Phenylbutazone drug:Acetylsalicylic acid drug:Pindolol drug:Sulfamethoxazole drug:Ketoconazole drug:Rifampicin drug:Ibuprofen drug:Glipizide drug:Capecitabine drug:Miconazole drug:Tolbutamide drug:Carvedilol drug:Sulfinpyrazone drug:Acebutolol drug:Zopiclone drug:Nadolol drug:Ketamine drug:Paclitaxel drug:Gemfibrozil drug:Lumiracoxib drug:Fosphenytoin drug:Mestranol drug:Acenocoumarol drug:Oxprenolol drug:Sitaxentan drug:DBMET00289

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt

The resource appears as object in 123 triples

Context graph