Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01142"

Predicate	Value (sorted: default)
rdfs:label	"Doxepin"
rdf:type	drugbank:drugs
drugbank:description	"Doxepin hydrochloride is a dibenzoxepin-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, doxepin does not affect mood or arousal, but may cause sedation. In depressed individuals, doxepin exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as doxepin and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Doxepin has less sedative and anticholinergic effects than amitriptyline. See toxicity section below for a complete listing of side effects. Doxepin may be used to treat depression and insomnia. Unlabeled indications include chronic and neuropathic pain, and anxiety. Doxepin may also be used as a second line agent to treat idiopathic urticaria. "
drugbank:drugCategory	drugcategory:Adrenergic Uptake Inhibitors drugcategory:Antidepressive Agents
drugbank:interactsWith	drug:Fluvoxamine drug:Tramadol drug:Trospium drug:Butabarbital drug:Butalbital drug:Ziprasidone drug:Venlafaxine drug:Zolmitriptan drug:Terfenadine drug:Grepafloxacin drug:Norepinephrine drug:Tacrine drug:Phenylephrine drug:Phenylpropanolamine drug:Triprolidine drug:Fluoxetine drug:Altretamine drug:Cimetidine drug:Ritonavir drug:Toremifene drug:Carbamazepine drug:Clonidine drug:Voriconazole drug:Cisapride drug:Metaraminol drug:Rifabutin drug:Trazodone drug:Trimethobenzamide drug:Epinephrine drug:Galantamine drug:Thioridazine drug:Methoxamine drug:Trimipramine drug:Thiabendazole drug:Tranylcypromine drug:Phenelzine drug:Orciprenaline drug:Dobutamine drug:Donepezil drug:Pseudoephedrine drug:Terbinafine drug:Tacrolimus drug:Terbutaline drug:Quinidine drug:Mesoridazine drug:Telithromycin drug:Dopamine drug:Rivastigmine drug:Salbutamol drug:Rifampicin drug:Isoprenaline drug:Atazanavir drug:Sibutramine drug:Guanethidine drug:Moclobemide drug:Sparfloxacin drug:Isocarboxazid drug:Fenoterol drug:Pirbuterol drug:Dihydroquinidine barbiturate drug:Quinidine barbiturate drug:Ephedra drug:Ephedrine drug:Mephentermine drug:Procaterol drug:Rasagiline drug:Thiothixene drug:Zuclopenthixol drug:Vorinostat drug:Artemether drug:Desvenlafaxine drug:Lumefantrine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate
owl:sameAs	drug:APRD00398 drug:BE0002363 drug:BE0002433 drug:BE0002638 drug:BE0002793 drug:BE0003536 drug:Fluvoxamine drug:Tramadol drug:Trospium drug:Butabarbital drug:Butalbital drug:Ziprasidone drug:Venlafaxine drug:Zolmitriptan drug:Terfenadine drug:Grepafloxacin drug:Norepinephrine drug:Tacrine drug:Phenylephrine drug:Phenylpropanolamine drug:Triprolidine drug:Fluoxetine drug:Altretamine drug:Cimetidine drug:Ritonavir drug:Toremifene drug:Carbamazepine drug:Clonidine drug:Voriconazole drug:Cisapride drug:Metaraminol drug:Rifabutin drug:Trazodone drug:Trimethobenzamide drug:Epinephrine drug:Galantamine drug:Thioridazine drug:Methoxamine drug:Trimipramine drug:Thiabendazole drug:Tranylcypromine drug:Phenelzine drug:Orciprenaline drug:Dobutamine drug:Donepezil drug:Pseudoephedrine drug:Terbinafine drug:Tacrolimus drug:Terbutaline drug:Quinidine drug:Mesoridazine drug:Telithromycin drug:Dopamine drug:Rivastigmine drug:Salbutamol drug:Rifampicin drug:Isoprenaline drug:Atazanavir drug:Sibutramine drug:Doxepin drug:Guanethidine drug:Moclobemide drug:Sparfloxacin drug:Isocarboxazid drug:Fenoterol drug:Pirbuterol drug:Dihydroquinidine barbiturate drug:Quinidine barbiturate drug:Ephedra drug:Ephedrine drug:Mephentermine drug:Procaterol drug:Rasagiline drug:Thiothixene drug:Zuclopenthixol drug:Vorinostat drug:Artemether drug:Desvenlafaxine drug:Lumefantrine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate drug:DBMET00315 drug:DBMET00834 drug:DBMET00844 drug:DBMET00845 drug:DBMET00872 drug:DBMET00873 drug:DBMET00875 drug:DBMET00876 drug:DBMET00877 drug:DBMET00878 drug:DBMET00879 drug:DBMET00881 drug:DBSALT000059

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt

The resource appears as object in 149 triples

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