Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01175"

Predicate	Value (sorted: default)
rdfs:label	"Escitalopram"
rdf:type	drugbank:drugs
drugbank:description	"Escitalopram, the <i>S</i>-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize &alpha;- or &beta;-adrenergic, dopamine D<sub>2</sub> or histamine H<sub>1</sub> receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). "
drugbank:drugCategory	drugcategory:Antidepressive Agents, Second-Generation drugcategory:Serotonin Uptake Inhibitors
drugbank:interactsWith	drug:Tramadol drug:Ticlopidine drug:Eletriptan drug:Ziprasidone drug:Metoprolol drug:Venlafaxine drug:Zolmitriptan drug:Treprostinil drug:Triprolidine drug:Oxycodone drug:Tolmetin drug:Propranolol drug:Voriconazole drug:Linezolid drug:Trazodone drug:Sumatriptan drug:Trimipramine drug:Tranylcypromine drug:Phenelzine drug:Almotriptan drug:Naratriptan drug:Rizatriptan drug:Telithromycin drug:Frovatriptan drug:Ketoprofen drug:Selegiline drug:Pimozide drug:Sibutramine drug:Carvedilol drug:Isocarboxazid drug:St. John's Wort drug:Rasagiline drug:Ginkgo biloba drug:Tiaprofenic acid drug:Zuclopenthixol drug:Telaprevir drug:Artemether drug:Desvenlafaxine drug:Lumefantrine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate
owl:sameAs	drug:APRD00683 drug:Tramadol drug:Ticlopidine drug:Eletriptan drug:Ziprasidone drug:Metoprolol drug:Venlafaxine drug:Zolmitriptan drug:Treprostinil drug:Triprolidine drug:Oxycodone drug:Tolmetin drug:Propranolol drug:Voriconazole drug:Linezolid drug:Trazodone drug:Sumatriptan drug:Trimipramine drug:Tranylcypromine drug:Phenelzine drug:Almotriptan drug:Naratriptan drug:Rizatriptan drug:Telithromycin drug:Frovatriptan drug:Ketoprofen drug:Selegiline drug:Pimozide drug:Sibutramine drug:Carvedilol drug:Isocarboxazid drug:St. John's Wort drug:Rasagiline drug:Ginkgo biloba drug:Tiaprofenic acid drug:Zuclopenthixol drug:Telaprevir drug:Artemether drug:Desvenlafaxine drug:Lumefantrine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt

The resource appears as object in 82 triples

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