Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01242"

Predicate	Value (sorted: default)
rdfs:label	"Clomipramine"
rdf:type	drugbank:drugs
drugbank:description	"Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, clomipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as clomipramine, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Clomipramine may be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette’s disorder). Unlabeled indications include panic disorder, chronic pain (e.g. central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, neuropathic pain), cataplexy and associated narcolepsy, autistic disorder, trichotillomania, onchophagia, stuttering, premature ejaculation, and premenstrual syndrome. Clomipramine is rapidly absorbed from the gastrointestinal tract and demethylated in the liver to its primary active metabolite, desmethylclomipramine. "
drugbank:drugCategory	drugcategory:Antidepressive Agents, Tricyclic drugcategory:Serotonin Uptake Inhibitors
drugbank:interactsWith	drug:Fluvoxamine drug:Tramadol drug:Ticlopidine drug:Trospium drug:Butabarbital drug:Butalbital drug:Ziprasidone drug:Venlafaxine drug:Zolmitriptan drug:Terfenadine drug:Grepafloxacin drug:Norepinephrine drug:Tacrine drug:Phenylephrine drug:Phenylpropanolamine drug:Triprolidine drug:Fluoxetine drug:Altretamine drug:Cimetidine drug:Ritonavir drug:Toremifene drug:Clonidine drug:Voriconazole drug:Cisapride drug:Metaraminol drug:Rifabutin drug:Trazodone drug:Trimethobenzamide drug:Epinephrine drug:Galantamine drug:Tamoxifen drug:Tamsulosin drug:Methoxamine drug:Trimipramine drug:Thiabendazole drug:Tranylcypromine drug:Phenelzine drug:Orciprenaline drug:Dobutamine drug:Donepezil drug:Pseudoephedrine drug:Terbinafine drug:Tacrolimus drug:Terbutaline drug:Quinidine drug:Dopamine drug:Rivastigmine drug:Salbutamol drug:Rifampicin drug:Isoprenaline drug:Atazanavir drug:Sibutramine drug:Guanethidine drug:Moclobemide drug:Sparfloxacin drug:Isocarboxazid drug:Fenoterol drug:Pirbuterol drug:Dihydroquinidine barbiturate drug:Quinidine barbiturate drug:Ephedra drug:Ephedrine drug:Mephentermine drug:Procaterol drug:Rasagiline drug:Thiothixene drug:Zuclopenthixol drug:Vorinostat drug:Artemether drug:Desvenlafaxine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate
owl:sameAs	drug:APRD00253 drug:BE0002363 drug:BE0002433 drug:BE0002638 drug:BE0003536 drug:Fluvoxamine drug:Tramadol drug:Ticlopidine drug:Trospium drug:Butabarbital drug:Butalbital drug:Ziprasidone drug:Venlafaxine drug:Zolmitriptan drug:Terfenadine drug:Grepafloxacin drug:Norepinephrine drug:Tacrine drug:Phenylephrine drug:Phenylpropanolamine drug:Triprolidine drug:Fluoxetine drug:Altretamine drug:Cimetidine drug:Ritonavir drug:Toremifene drug:Clonidine drug:Voriconazole drug:Cisapride drug:Metaraminol drug:Rifabutin drug:Trazodone drug:Trimethobenzamide drug:Epinephrine drug:Galantamine drug:Tamoxifen drug:Tamsulosin drug:Methoxamine drug:Trimipramine drug:Thiabendazole drug:Tranylcypromine drug:Phenelzine drug:Orciprenaline drug:Dobutamine drug:Donepezil drug:Pseudoephedrine drug:Terbinafine drug:Tacrolimus drug:Terbutaline drug:Quinidine drug:Dopamine drug:Rivastigmine drug:Salbutamol drug:Rifampicin drug:Isoprenaline drug:Atazanavir drug:Sibutramine drug:Guanethidine drug:Moclobemide drug:Sparfloxacin drug:Clomipramine drug:Isocarboxazid drug:Fenoterol drug:Pirbuterol drug:Dihydroquinidine barbiturate drug:Quinidine barbiturate drug:Ephedra drug:Ephedrine drug:Mephentermine drug:Procaterol drug:Rasagiline drug:Thiothixene drug:Zuclopenthixol drug:Vorinostat drug:Artemether drug:Desvenlafaxine drug:DB07600 drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate drug:DBMET00244 drug:DBMET00682 drug:DBMET00777 drug:DBMET00817 drug:DBMET00835 drug:DBMET01069 drug:DBMET01071 drug:DBMET01072 drug:DBMET01073 drug:DBMET01074 drug:DBMET01075 drug:DBSALT000028

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The resource appears as object in 145 triples

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