Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01291"

Predicate	Value (sorted: default)
rdfs:label	"Pirbuterol"
rdf:type	drugbank:drugs
drugbank:description	"Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established. The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. "
drugbank:drugCategory	drugcategory:Adrenergic beta-2 Receptor Agonists drugcategory:Bronchodilator Agents drugcategory:Cardiotonic Agents
drugbank:interactsWith	drug:Esmolol drug:Reserpine drug:Midodrine drug:Metoprolol drug:Amitriptyline drug:Atenolol drug:Timolol drug:Imipramine drug:Nortriptyline drug:Amoxapine drug:Propranolol drug:Labetalol drug:Linezolid drug:Bisoprolol drug:Phenelzine drug:Pindolol drug:Methyldopa drug:Carvedilol drug:Doxepin drug:Desipramine drug:Moclobemide drug:Acebutolol drug:Nadolol drug:Clomipramine drug:Isocarboxazid drug:Rasagiline drug:Oxprenolol
owl:sameAs	drug:Esmolol drug:Reserpine drug:Midodrine drug:Metoprolol drug:Amitriptyline drug:Atenolol drug:Timolol drug:Imipramine drug:Nortriptyline drug:Amoxapine drug:Propranolol drug:Labetalol drug:Linezolid drug:Bisoprolol drug:Phenelzine drug:Pindolol drug:Methyldopa drug:Carvedilol drug:Doxepin drug:Desipramine drug:Moclobemide drug:Acebutolol drug:Nadolol drug:Clomipramine drug:Isocarboxazid drug:Rasagiline drug:Oxprenolol drug:DBSALT000798 drug:DBSALT000799

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt

The resource appears as object in 54 triples

Context graph