Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01341"

Predicate	Value (sorted: default)
rdfs:label	"Dihydroquinidine barbiturate"
rdf:type	drugbank:drugs
drugbank:description	" experimental Barbiturates work by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding sites that are distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. This GABAA receptor binding decreases input resistance, depresses burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increases both the amplitude and decay time of inhibitory postsynaptic currents. In addition to this GABA-ergic effect, barbiturates also block the AMPA receptor, a subtype of glutamate receptor. Glutamate is the principal excitatory neurotransmitter in the mammalian CNS. DB00594 Amiloride Decreases the antiarrhythmic effect of quinidine DB01223 Aminophylline The barbiturate, dihydroquinidine barbiturate, decreases the effect of aminophylline. DB01118 Amiodarone Increases the effect of quinidine DB00321 Amitriptyline Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, amitriptyline. DB01238 Aripiprazole Quinidine increases the effect and toxicity of aripiprazole DB01072 Atazanavir Increased risk of cardiotoxicity and arrhythmias DB00443 Betamethasone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, betamethasone. DB00501 Cimetidine Increases the effect of quinidine DB00604 Cisapride Increased risk of cardiotoxicity and arrhythmias DB01242 Clomipramine Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, clomipramine. DB00318 Codeine Quinidine decreases the analgesic effect of codeine DB00091 Cyclosporine The barbiturate, dihydroquinidine barbiturate, increases the effect of cyclosporine. DB01151 Desipramine Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, desipramine. DB01234 Dexamethasone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, dexamethasone. DB00514 Dextromethorphan Quinidine increases the toxicity of dextromethorphan DB00390 Digoxin Quinine/quinidine increases the effect of digoxin DB00343 Diltiazem Increases the effect and toxicity of quinidine DB01142 Doxepin Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, doxepin. DB00254 Doxycycline The anticonvulsant, dihydroquinidine barbiturate, decreases the effect of doxycycline. DB01023 Felodipine The barbiturate, dihydroquinidine barbiturate, decreases the effect of felodipine. DB00687 Fludrocortisone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, fludrocortisone. DB00158 Folic Acid Folic acid decreases the effect of anticonvulsant, dihydroquinidine barbiturate. DB01044 Gatifloxacin Increased risk of cardiotoxicity and arrhythmias DB00317 Gefitinib The CYP3A4 inducer, dihydroquinidine barbiturate, may decrease the serum concentration and therapeutic effects of gefitinib. DB00365 Grepafloxacin Increased risk of cardiotoxicity and arrhythmias DB00400 Griseofulvin The barbiturate, dihydroquinidine barbiturate, decreases the effect of griseofulvin. DB00741 Hydrocortisone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, hydrocortisone. DB00458 Imipramine Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, imipramine. DB01137 Levofloxacin Increased risk of cardiotoxicity and arrhythmias DB00367 Levonorgestrel Phenobarbital decreases the effect of levonorgestrel DB01378 Magnesium The antiacid decreases the absorption of quinidine DB00333 Methadone The barbiturate, dihydroquinidine barbiturate, decreases the effect of methadone. DB00916 Metronidazole The barbiturate, dihydroquinidine barbiturate, decreases the effect of metronidazole. DB00218 Moxifloxacin Increased risk of cardiotoxicity and arrhythmias DB00220 Nelfinavir Nelfinavir increases the effect and toxicity of quindine DB01115 Nifedipine Decreased quinidine effect, increased nifedipine effect DB00540 Nortriptyline Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, nortriptyline. DB01165 Ofloxacin Increased risk of cardiotoxicity and arrhythmias DB01303 Oxtriphylline The barbiturate, dihydroquinidine barbiturate, decreases the effect of oxtriphylline. DB00860 Prednisolone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, prednisolone. DB00635 Prednisone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, prednisone. DB01035 Procainamide Quinidine increases the effect of procainamide DB01182 Propafenone Quinidine increases the effect of propafenone DB00908 Quinidine The anticonvulsant, dihydroquinidine. barbiturate, decreases the effect of quinidine. DB01369 Quinupristin This combination presents an increased risk of toxicity DB00277 Theophylline The barbiturate, dihydroquinidine barbiturate, decreases the effect of theophylline. DB00620 Triamcinolone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, triamcinolone. BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Human potentiator # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 yes Gamma-aminobutyric acid receptor subunit alpha-1 Involved in GABA-A receptor activity GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel GABRA1 5q34-q35 Membrane; multi-pass membrane protein 252-273 279-300 313-334 422-443 9.61 51802.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:4075 GenAtlas GABRA1 GeneCards GABRA1 GenBank Gene Database X13584 GenBank Protein Database 31631 IUPHAR 404 Guide to Pharmacology 72 UniProtKB P14867 UniProt Accession GBRA1_HUMAN Gamma-aminobutyric-acid receptor subunit alpha-1 precursor >Gamma-aminobutyric-acid receptor subunit alpha-1 precursor MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ >1371 bp ATGAGGAAAAGTCCAGGTCTGTCTGACTGTCTTTGGGCCTGGATCCTCCTTCTGAGCACA CTGACTGGAAGAAGCTATGGACAGCCGTCATTACAAGATGAACTTAAAGACAATACCACT GTCTTCACCAGGATTTTGGACAGACTCCTAGATGGTTATGACAATCGCCTGAGACCAGGA TTGGGAGAGCGTGTAACCGAAGTGAAGACTGATATCTTCGTCACCAGTTTCGGACCCGTT TCAGACCATGATATGGAATATACAATAGATGTATTTTTCCGTCAAAGCTGGAAGGATGAA AGGTTAAAATTTAAAGGACCTATGACAGTCCTCCGGTTAAATAACCTAATGGCAAGTAAA ATCTGGACTCCGGACACATTTTTCCACAATGGAAAGAAGTCAGTGGCCCACAACATGACC ATGCCCAACAAACTCCTGCGGATCACAGAGGATGGCACCTTGCTGTACACCATGAGGCTG ACAGTGAGAGCTGAATGTCCGATGCATTTGGAGGACTTCCCTATGGATGCCCATGCTTGC CCACTAAAATTTGGAAGTTATGCTTATACAAGAGCAGAAGTTGTTTATGAATGGACCAGA GAGCCAGCACGCTCAGTGGTTGTAGCAGAAGATGGATCACGTCTAAACCAGTATGACCTT CTTGGACAAACAGTAGACTCTGGAATTGTCCAGTCAAGTACAGGAGAATATGTTGTTATG ACCACTCATTTCCACTTGAAGAGAAAGATTGGCTACTTTGTTATTCAAACATACCTGCCA TGCATAATGACAGTGATTCTCTCACAAGTCTCCTTCTGGCTCAACAGAGAGTCTGTACCA GCAAGAACTGTCTTTGGAGTAACAACTGTGCTCACCATGACAACATTGAGCATCAGTGCC AGAAACTCCCTCCCTAAGGTGGCTTATGCAACAGCTATGGATTGGTTTATTGCCGTGTGC TATGCCTTTGTGTTCTCAGCTCTGATTGAGTTTGCCACAGTAAACTATTTCACTAAGAGA GGTTATGCATGGGATGGCAAAAGTGTGGTTCCAGAAAAGCCAAAGAAAGTAAAGGATCCT CTTATTAAGAAAAACAACACTTACGCTCCAACAGCAACCAGCTACACCCCTAATTTGGCC AGGGGCGACCCGGGCTTAGCCACCATTGCTAAAAGTGCAACCATAGAACCTAAAGAGGTC AAGCCCGAAACAAAACCACCAGAACCCAAGAAAACCTTTAACAGTGTCAGCAAAATTGAC CGACTGTCAAGAATAGCCTTCCCGCTGCTATTTGGAATCTTTAACTTAGTCTACTGGGCT ACGTATTTAAACAGAGAGCCTCAGCTAAAAGCCCCCACACCACATCAATAG PF02931 Neur_chan_LBD PF02932 Neur_chan_memb component intrinsic to membrane component integral to membrane component membrane component postsynaptic membrane component cell function GABA receptor activity function ion transporter activity function GABA-A receptor activity function ion channel activity function signal transducer activity function ligand-gated ion channel activity function receptor activity function extracellular ligand-gated ion channel activity function transporter activity function transmembrane receptor activity function neurotransmitter receptor activity process signal transduction process cell surface receptor linked signal transduction process gamma-aminobutyric acid signaling pathway process ion transport process G-protein coupled receptor protein signaling pathway process anion transport process inorganic anion transport process chloride transport process physiological process process cellular physiological process process transport process cellular process process cell communication "
drugbank:interactsWith	drug:Cyclosporine drug:Folic Acid drug:Moxifloxacin drug:Nelfinavir drug:Doxycycline drug:Theophylline drug:Gefitinib drug:Codeine drug:Amitriptyline drug:Methadone drug:Diltiazem drug:Grepafloxacin drug:Levonorgestrel drug:Digoxin drug:Griseofulvin drug:Betamethasone drug:Imipramine drug:Cimetidine drug:Dextromethorphan drug:Nortriptyline drug:Amiloride drug:Cisapride drug:Triamcinolone drug:Prednisone drug:Fludrocortisone drug:Hydrocortisone drug:Prednisolone drug:Quinidine drug:Metronidazole drug:Felodipine drug:Procainamide drug:Gatifloxacin drug:Atazanavir drug:Nifedipine drug:Amiodarone drug:Levofloxacin drug:Doxepin drug:Desipramine drug:Ofloxacin drug:Propafenone drug:Aminophylline drug:Dexamethasone drug:Aripiprazole drug:Clomipramine drug:Oxtriphylline drug:Quinupristin drug:Magnesium
owl:sameAs	drug:Cyclosporine drug:Folic Acid drug:Moxifloxacin drug:Nelfinavir drug:Doxycycline drug:Theophylline drug:Gefitinib drug:Codeine drug:Amitriptyline drug:Methadone drug:Diltiazem drug:Grepafloxacin drug:Levonorgestrel drug:Digoxin drug:Griseofulvin drug:Betamethasone drug:Imipramine drug:Cimetidine drug:Dextromethorphan drug:Nortriptyline drug:Amiloride drug:Cisapride drug:Triamcinolone drug:Prednisone drug:Fludrocortisone drug:Hydrocortisone drug:Prednisolone drug:Quinidine drug:Metronidazole drug:Felodipine drug:Procainamide drug:Gatifloxacin drug:Atazanavir drug:Nifedipine drug:Amiodarone drug:Levofloxacin drug:Doxepin drug:Desipramine drug:Ofloxacin drug:Propafenone drug:Aminophylline drug:Dexamethasone drug:Aripiprazole drug:Clomipramine drug:Oxtriphylline drug:Quinupristin drug:Magnesium

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The resource appears as object in 94 triples

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