Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01399"

Predicate	Value (sorted: default)
rdfs:label	"Salsalate"
rdf:type	drugbank:drugs
drugbank:description	"Salsalate is a nonsteroidal anti-inflammatory agent for oral administration. Salsalate's mode of action as an anti-inflammatory and antirheumatic agent may be due to inhibition of synthesis and release of prostaglandins. The usefulness of salicylic acid, the active in vivo product of salsalate, in the treatment of arthritic disorders has been established. In contrast to aspirin, salsalate causes no greater fecal gastrointestinal blood loss than placebo. Salsalate is readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged and undergoes rapid esterase hydrolysis in the body. The parent compound has an elimination half-life of about 1 hour. Salicylic acid (the active metabolite) biotransformation is saturated at anti-inflammatory doses of salsalate. Such capacity limited biotransformation results in an increase in the half-life of salicylic acid from 3.5 to 16 or more hours."
drugbank:drugCategory	drugcategory:Anti-Inflammatory Agents, Non-Steroidal
drugbank:interactsWith	drug:Treprostinil drug:Betamethasone drug:Tolmetin drug:Trandolapril drug:Methotrexate drug:Sulindac drug:Triamcinolone drug:Prednisone drug:Chlorpropamide drug:Fludrocortisone drug:Methazolamide drug:Hydrocortisone drug:Prednisolone drug:Glyburide drug:Probenecid drug:Gliclazide drug:Dexamethasone drug:Tiaprofenic acid
owl:sameAs	drug:L-Glutamic Acid drug:Glutathione drug:Treprostinil drug:Betamethasone drug:Tolmetin drug:Trandolapril drug:Methotrexate drug:Sulindac drug:Triamcinolone drug:Prednisone drug:Chlorpropamide drug:Fludrocortisone drug:Methazolamide drug:Hydrocortisone drug:Prednisolone drug:Glyburide drug:Probenecid drug:Gliclazide drug:Dexamethasone drug:Calcium drug:Salsalate drug:Zinc drug:Tiaprofenic acid drug:Arachidonic Acid

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt

The resource appears as object in 42 triples

Context graph