Resource Ribavirin Monophosphate

Predicate	Value (sorted: default)
rdfs:label	"Ribavirin Monophosphate"
rdf:type	drugbank:drugs
drugbank:description	" 40925-28-8 experimental This compound belongs to the triazole ribonucleosides and ribonucleotides. These are nucleoside derivatives containing a ribose derivative which is n-glycosylated to a triazole. Triazole Ribonucleosides and Ribonucleotides Organic Compounds Organooxygen Compounds Carbohydrates and Carbohydrate Conjugates Glycosyl Compounds Pentose Phosphates Monosaccharide Phosphates Triazole Carboxamides Organophosphate Esters Organic Phosphoric Acids Oxolanes Tetrahydrofurans 1,2-Diols Secondary Alcohols Primary Carboxylic Acid Amides Ethers Enolates Carboxylic Acids Polyamines monosaccharide phosphate pentose monosaccharide 1,2,4-triazole carboxamide 1,2,4-triazole carboxylic acid or derivative phosphoric acid ester organic phosphate monosaccharide oxolane azole tetrahydrofuran 1,2,4-triazole carboxamide group primary carboxylic acid amide 1,2-diol secondary alcohol enolate carboxylic acid derivative polyamine carboxylic acid ether organonitrogen compound amine alcohol DB01048 Abacavir Ribavirin Monophosphate may increase the hepatotoxicity of reverse transcriptase inhibitors (nucleoside) such as Abacavir. Lactic acidosis may occur. Consider modifying therapy. logP -2.7 ALOGPS logS -2 ALOGPS Water Solubility 3.34e+00 g/l ALOGPS logP -2.9 ChemAxon IUPAC Name {[(2S,3R,4R,5R)-5-(3-carbamoyl-1H-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid ChemAxon Traditional IUPAC Name [(2S,3R,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxyphosphonic acid ChemAxon Molecular Weight 324.1846 ChemAxon Monoisotopic Weight 324.047099924 ChemAxon SMILES NC(=O)C1=NN(C=N1)[C@@H]1O[C@@H](COP(O)(O)=O)[C@H](O)[C@H]1O ChemAxon Molecular Formula C8H13N4O8P ChemAxon InChI InChI=1S/C8H13N4O8P/c9-6(15)7-10-2-12(11-7)8-5(14)4(13)3(20-8)1-19-21(16,17)18/h2-5,8,13-14H,1H2,(H2,9,15)(H2,16,17,18)/t3-,4-,5+,8+/m0/s1 ChemAxon InChIKey InChIKey=SDWIOXKHTFOULX-PDNLFSCWSA-N ChemAxon Polar Surface Area (PSA) 190.25 ChemAxon Refractivity 75.45 ChemAxon Polarizability 26.6 ChemAxon Rotatable Bond Count 5 ChemAxon H Bond Acceptor Count 9 ChemAxon H Bond Donor Count 5 ChemAxon pKa (strongest acidic) 1.23 ChemAxon pKa (strongest basic) -1.2 ChemAxon Physiological Charge -2 ChemAxon Number of Rings 2 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon PubChem Compound 5748447 PubChem Substance 46504726 ChemSpider 284811 PDB RVP BE0001261 Genome polyprotein DENV-2 # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Genome polyprotein Involved in nucleic acid binding The small proteins NS2A, NS4A and NS4B are hydrophobic, suggesting a possible membrane-related function. NS5 may play a role in the viral RNA replication. The NS2B/NS3 protease complex processes the viral polyprotein Cytoplasmic 43-59 101-117 268-284 727-743 757-773 8.67 379224.0 DENV-2 GenBank Gene Database M19197 GenBank Protein Database 323655 UniProtKB P12823 UniProt Accession POLG_DEN2P Core protein EC 2.7.7.48 EC 3.4.21.91 Envelope protein M Flavivirin protease NS2B regulatory subunit Flavivirin protease NS3 catalytic subunit Genome polyprotein [Contains: Capsid protein C Major envelope protein E Matrix protein Non- structural protein 1 Non-structural protein 2A Non-structural protein 4A Non-structural protein 4B NS1 NS2A NS4A NS4B NS5] RNA-directed RNA polymerase >Genome polyprotein [Contains: Capsid protein C MNDQRKKARNTPFNMLKRERNRVSTVQQLTKRFSLGMLQGRGPLKLFMALVAFLRFLTIP PTAGILKRWGTIKKSKAINVLRGFRKEIGRMLNILNRRRRTAGMIIMLIPTVMAFHLTTR NGEPHMIVSRQEKGKSLLFKTKDGTNMCTLMAMDLGELCEDTITYKCPFLKQNEPEDIDC WCNSTSTWVTYGTCTTTGEHRREKRSVALVPHVGMGLETRTETWMSSEGAWKHAQRIETW ILRHPGFTIMAAILAYTIGTTHFQRVLIFILLTAIAPSMTMRCIGISNRDFVEGVSGGSW VDIVLEHGSCVTTMAKNKPTLDFELIKTEAKQPATLRKYCIEAKLTNTTTDSRCPTQGEP TLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKIVQPENLEYTVV ITPHSGEEHAVGNDTGKHGKEVKITPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQ MKDKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAM HTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTI VIRVQYEGDGSPCKTPFEIMDLEKRHVLGRLTTVNPIVTEKDSPVNIEAEPPFGDSYIII GVEPGQLKLDWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVF GAIYGAAFSGVSWTMKILIGVIITWIGMNSRSTSLSVSLVLVGIVTLYLGVMVQADSGCV VSWKNKELKCGSGIFVTDNVHTWTEQYKFQPESPSKLASAIQKAHEEGICGIRSVTRLEN LMWKQITSELNHILSENEVKLTIMTGDIKGIMQVGKRSLRPQPTELRYSWKTWGKAKMLS TELHNQTFLIDGPETAECPNTNRAWNSLEVEDYGFGVFTTNIWLRLREKQDAFCDSKLMS AAIKDNRAVHADMGYWIESALNDTWKIEKASFIEVKSCHWPKSHTLWSNGVLESEMVIPK NFAGPVSQHNNRPGYHTQTAGPWHLGKLEMDFDFCEGTTVVVTEDCGNRGPSLRTTTASG KLITEWCCRSCTLPPLRYRGEDGCWYGMEIRPLKEKEENLVSSLVTAGHGQIDNFSLGIL GMALFLEEMLRTRVGTKHAILLVAVSFVTLITGNMSFRDLGRVMVMVGATMTDDIGMGVT YLALLAAFKVRPTFAAGLLLRKLTSKELMMTTIGIVLLSQSSIPETILELTDALALGMMV LKMVRNMEKYQLAVTIMAILCVPNAVILQNAWKVSCTILAVVSVSPLFLTSSQQKADWIP LALTIKGLNPTAIFLTTLSRTSKKRSWPLNEAIMAVGMVSILASSLLKNDTPMTGPLVAG GLLTVCYVLTGRSADLELERATDVKWDDQAEISGSSPILSITISEDGSMSIKNEEEEQTL TILIRTGLLVISGLFPVSIPITAAAWYLWEVKKQRAGVLWDVPSPPPVGKAELEDGAYRI KQKGILGYSQIGAGVYKEGTFHTMWHVTRGAVLMHKGKRIEPSWADVKKDLISYGGGWKL EGEWKEGEEVQVLALEPGKNPRAVQTKPGLFRTNTGTIGAVSLDFSPGTSGSPIVDKKGK VVGLYGNGVVTRSGAYVSAIAQTEKSIEDNPEIEDDIFRKRRLTIMDLHPGAGKTKRYLP AIVREAIKRGLRTLILAPTRVVAAEMEEALRGLPIRYQTPAIRAEHTGREIVDLMCHATF TMRLLSPIRVPNYNLIIMDEAHFTDPASIAARGYISTRVEMGEAAGIFMTATPPGSRDPF PQSNAPIMDEEREIPERSWNSGHEWVTDFKGKTVWFVPSIKTGNDIAACLRKNGKRVIQL SRKTFDSEYVKTRTNDWDFVVTTDISEMGANFKAERVIDPRRCMKPVILTDGEERVILAG PMPVTHSSAAQRRGRIGRNPRNENDQYIYMGEPLENDEDCAHWKEAKMLLDNINTPEGII PSMFEPEREKVDAIDGEYRLRGEARKTFVDLMRRGDLPVWLAYKVAAEGINYADRRWCFD GTRNNQILEENVEVEIWTKEGERKKLKPRWLDARIYSDPLALKEFAAGRKSLTLNLITEM GRLPTFMTQKARDALDNLAVLHTAEAGGKAYNHALSELPETLETLLLLTLLATVTGGIFL FLMSGRGIGKMTLGMCCIITASILLWYAQIQPHWIAASIILEFFLIVLLIPEPEKQRTPQ DNQLTYVIIAILTVVAATMANEMGFLEKTKKDLGLGNIATQQPESNILDIDLRPASAWTL YAVATTFITPMLRHSIENSSVNVSLTAIANQATVLMGLGKGWPLSKMDIGVPLLAIGCYS QVNPITLTAALLLLVAHYAIIGPGLQAKATREAQKRAAAGIMKNPTVDGITVIDLDPIPY DPKFEKQLGQVMLLVLCVTQVLMMRTTWALCEALTLATGPVSTLWEGNPGRFWNTTIAVS MANIFRGSYLAGAGLLFSIMKNTTSTRRGTGNIGETLGEKWKSRLNALGKSEFQIYKKSG IQEVDRTLAKEGIKRGETDHHAVSRGSAKLRWFVERNLVTPEGKVVDLGCGRGGWSYYCG GLKNVREVKGLTKGGPGHEEPIPMSTYGWNLVRLQSGVDVFFVPPEKCDTLLCDIGESSP NPTVEAGRTLRVLNLVENWLNNNTQFCVKVLNPYMPSVIERMETLQRKYGGALVRNPLSR NSTHEMYWVSNASGNIVSSVNMISRMLINRFTMRHKKATYEPDVDLGSGTRNIGIESETP NLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPW DVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPR MCTREEFTKKVRSNAALGAIFTDENKWKSAREAVEDSRFWELVDKERNLHLEGKCETCVY NMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGL HKLGYILREVSKKEGGAMYADDTAGWDTRITIEDLKNEEMITNHMAGEHKKLAEAIFKLT YQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGIFKSI QHLTASEEIAVQDWLARVGRERLSRMAISGDDCVVKPLDDRFARALTALNDMGKVRKDIQ QWEPSRGWNDWTQVPFCSHHFHELIMKDGRTLVVPCRNQDELIGRARISQGAGWSLRETA CLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHASHEWMTTEDMLTV WNKVWILENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRS LIGNEEYTDYMPSMKRFRREEEEAGVLW >10167 bp ATGAATGACCAACGGAAAAAGGCGAGAAACACGCCTTTCAATATGCTGAAACGCGAGAGA AACCGCGTGTCAACTGTACAACAGTTGACAAAGAGATTCTCACTTGGAATGCTGCAGGGA CGAGGACCACTAAAATTGTTCATGGCCCTGGTGGCATTCCTTCGTTTCCTAACAATCCCA CCAACAGCAGGGATATTAAAAAGATGGGGAACAATTAAAAAATCAAAGGCTATTAATGTT CTGAGAGGCTTCAGGAAAGAGATTGGAAGGATGCTGAATATCTTAAACAGGAGACGTAGA ACTGCAGGCATGATCATCATGCTGATTCCAACAGTGATGGCGTTTCATCTGACCACACGC AACGGAGAACCACACATGATCGTCAGTAGACAAGAAAAAGGGAAAAGCCTTCTGTTTAAG ACAAAGGACGGCACGAACATGTGTACCCTCATGGCCATGGACCTTGGTGAGTTGTGTGAA GACACAATCACGTATAAATGTCCCTTTCTCAAGCAGAACGAACCAGAAGACATAGATTGT TGGTGCAACTCCACGTCCACATGGGTAACTTATGGGACATGTACCACCACAGGAGAGCAC AGAAGAGAAAAAAGATCAGTGGCGCTTGTTCCACACGTGGGAATGGGATTGGAGACACGA ACTGAAACATGGATGTCATCAGAAGGGGCCTGGAAACATGCCCAGAGAATTGAAACTTGG ATTCTGAGACATCCAGGCTTTACCATAATGGCCGCAATCCTGGCATACACCATAGGAACG ACGCATTTCCAAAGAGTCCTGATATTCATCCTACTGACAGCCATCGCTCCTTCAATGACA ATGCGCTGCATAGGAATATCAAATAGGGACTTTGTGGAAGGAGTGTCAGGAGGGAGTTGG GTTGACATAGTTTTAGAACATGGAAGTTGTGTGACGACGATGGCAAAAAATAAACCAACA CTGGACTTTGAACTGATAAAAACAGAAGCCAAACAACCCGCCACCTTAAGGAAGTACTGT ATAGAGGCTAAACTGACCAACACGACAACAGACTCGCGCTGCCCAACACAAGGGGAACCC ACCCTGAATGAAGAGCAGGACAAAAGGTTTGTCTGCAAACATTCCATGGTAGACAGAGGA TGGGGAAATGGATGTGGATTATTTGGAAAAGGAGGCATCGTGACCTGTGCCATGTTCACA TGCAAAAAGAACATGGAGGGAAAAATTGTGCAGCCAGAAAACCTGGAATACACTGTCGTT ATAACACCTCATTCAGGGGAAGAACATGCAGTCGGAAATGACACAGGAAAACATGGTAAA GAAGTCAAGATAACACCACAGAGCTCCATCACAGAGGCGGAACTGACAGGCTATGGCACT GTTACGATGGAGTGCTCTCCAAGAACGGGCCTCGACTTCAATGAGATGGTGTTGCTGCAA ATGAAAGACAAAGCTTGGCTGGTGCACAGACAATGGTTCCTAGACCTACCGTTGCCATGG CTGCCCGGAGCAGACACACAAGGATCAAATTGGATACAGAAAGAGACACTGGTCACCTTC AAAAATCCCCATGCGAAAAAACAGGATGTTGTTGTCTTAGGATCCCAAGAGGGGGCCATG CATACAGCACTCACAGGGGCTACGGAAATCCAGATGTCATCAGGAAACCTGCTGTTCACA GGACATCTTAAGTGCAGGCTGAGAATGGACAAATTACAACTTAAAGGGATGTCATACTCC ATGTGCACAGGAAAGTTTAAAGTTGTGAAGGAAATAGCAGAAACACAACATGGAACAATA GTCATTAGAGTACAATATGAAGGAGACGGCTCTCCATGCAAGACCCCTTTTGAGATAATG GATCTGGAAAAAAGACATGTTTTGGGCCGCCTGACCACAGTCAACCCAATTGTAACAGAA AAGGACAGTCCAGTCAACATAGAAGCAGAACCTCCATTCGGAGACAGCTACATCATCATA GGAGTGGAACCAGGACAATTGAAGCTGGACTGGTTCAAGAAAGGAAGTTCCATCGGCCAA ATGTTTGAGACAACAATGAGGGGAGCGAAAAGAATGGCCATTTTGGGCGACACAGCCTGG GATTTTGGATCTCTGGGAGGAGTGTTCACATCAATAGGAAAGGCTCTCCACCAGGTTTTT GGAGCAATCTACGGGGCTGCTTTCAGTGGGGTCTCATGGACTATGAAGATCCTCATAGGA GTTATCATCACATGGATAGGAATGAACTCACGTAGCACATCACTGTCTGTGTCACTGGTA TTAGTGGGAATCGTGACACTGTACTTGGGAGTTATGGTGCAGGCCGATAGTGGTTGCGTT GTGAGCTGGAAGAACAAAGAACTAAAATGTGGCAGTGGAATATTCGTCACAGATAACGTG CATACATGGACAGAACAATACAAGTTCCAACCAGAATCCCCTTCAAAACTGGCTTCAGCC ATCCAGAAAGCTCATGAAGAGGGCATCTGTGGAATCCGCTCAGTAACAAGACTGGAAAAT CTTATGTGGAAACAAATAACATCAGAATTGAATCATATTCTATCAGAAAATGAAGTGAAA CTGACCATCATGACAGGAGACATCAAAGGAATCATGCAGGTAGGAAAACGATCTCTGCGG CCTCAACCCACTGAGTTGAGGTATTCATGGAAAACATGGGGTAAAGCGAAAATGCTCTCC ACAGAACTCCATAATCAGACCTTCCTCATTGATGGTCCCGAAACAGCAGAATGCCCCAAC ACAAACAGAGCTTGGAATTCACTAGAAGTTGAGGACTACGGCTTTGGAGTATTCACTACC AATATATGGCTAAGATTGAGAGAAAAGCAGGATGCATTTTGTGACTCAAAACTCATGTCA GCGGCCATAAAGGACAACAGAGCCGTCCATGCTGATATGGGTTATTGGATAGAAAGCGCA CTCAATGATACATGGAAGATAGAGAAAGCTTCTTTCATTGAAGTCAAAAGTTGCCACTGG CCAAAGTCACACACTCTATGGAGTAATGGAGTGCTAGAAAGCGAGATGGTAATTCCAAAG AATTTCGCTGGACCAGTGTCACAACATAATAACAGACCAGGCTATCACACACAAACAGCA GGACCTTGGCATCTAGGCAAGCTTGAGATGGACTTTGATTTCTGCGAAGGGACTACAGTG GTGGTAACCGAGGACTGTGGAAACAGAGGGCCCTCTTTAAGAACAACCACTGCCTCAGGA AAACTCATAACGGAATGGTGTTGTCGATCTTGCACACTACCACCACTAAGATACAGAGGT GAGGATGGATGCTGGTACGGGATGGAAATCAGACCATTGAAAGAGAAAGAAGAAAATCTG GTCAGTTCTCTGGTCACAGCCGGACATGGGCAGATTGATAATTTCTCATTAGGAATCTTG GGAATGGCACTGTTCCTTGAAGAAATGCTCAGGACTCGAGTAGGAACGAAACATGCAATA TTACTAGTCGCAGTTTCTTTCGTAACGTTAATCACAGGGAACATGTCTTTTAGAGACCTG GGAAGAGTGATGGTTATGGTGGGTGCCACCATGACAGATGACATAGGCATGGGTGTGACT TATCTTGCTCTACTAGCAGCTTTCAAAGTCAGACCAACCTTTGCAGCTGGACTGCTCTTG AGAAAACTGACCTCCAAGGAATTAATGATGACCACCATAGGAATCGTTCTTCTCTCCCAG AGTAGCATACCAGAGACCATTCTTGAACTGACCGATGCGTTAGCTTTAGGCATGATGGTC CTCAAGATGGTGAGAAACATGGAAAAATATCAGCTGGCAGTGACCATCATGGCTATTTTG TGCGTCCCAAATGCTGTGATATTACAGAACGCATGGAAAGTGAGTTGCACAATATTGGCA GTGGTGTCTGTTTCCCCCCTGTTCTTAACATCCTCACAACAGAAAGCGGACTGGATACCA TTAGCGTTGACGATCAAAGGCCTCAATCCAACAGCCATTTTTCTAACAACCCTCTCAAGA ACCAGCAAGAAAAGGAGCTGGCCTTTAAATGAGGCCATCATGGCGGTTGGGATGGTGAGT ATCTTGGCCAGCTCTCTCTTAAAGAATGACACCCCCATGACAGGACCATTAGTGGCTGGA GGGCTTCTTACTGTGTGCTACGTACTAACTGGGCGGTCAGCCGATCTGGAACTAGAGAGA GCTACCGATGTCAAATGGGATGACCAGGCAGAGATATCAGGTAGCAGTCCAATTCTGTCA ATAACAATATCAGAAGATGGCAGCATGTCAATAAAGAATGAAGAGGAAGAGCAAACATTG ACTATACTCATTAGAACAGGATTGCTTGTGATCTCAGGACTCTTTCCGGTATCAATACCA ATTACAGCAGCAGCATGGTACCTGTGGGAAGTAAAGAAACAACGGGCTGGAGTGTTGTGG GATGTCCCCTCACCACCACCCGTGGGAAAGGCTGAATTGGAAGATGGAGCCTACAGAATC AAGCAAAAAGGAATCCTTGGATATTCCCAGATCGGAGCTGGAGTTTACAAAGAAGGAACA TTTCACACAATGTGGCACGTCACACGTGGCGCTGTCCTAATGCATAAGGGGAAGAGGATT GAACCATCATGGGCGGACGTCAAGAAAGACTTAATATCATATGGAGGAGGTTGGAAGCTA GAAGGAGAATGGAAAGAAGGAGAAGAAGTCCAGGTCTTGGCATTGGAGCCTGGGAAAAAT CCAAGAGCCGTCCAAACAAAACCTGGCCTTTTTAGAACCAATACTGGAACCATAGGTGCC GTATCTCTGGACTTTTCCCCTGGGACGTCAGGATCTCCAATCGTCGACAAAAAAGGAAAA GTTGTAGGCCTCTATGGCAATGGTGTCGTTACAAGGAGTGGAGCATATGTGAGTGCCATA GCTCAGACTGAAAAAAGCATTGAAGACAATCCAGAGATTGAAGATGACATCTTTCGAAAG AGAAGATTGACTATCATGGATCTCCACCCAGGAGCAGGAAAGACAAAGAGATACCTCCCG GCCATAGTCAGAGAGGCCATAAAAAGAGGCTTGAGAACACTAATCCTAGCCCCCACTAGA GTCGTGGCAGCTGAAATGGAGGAAGCCCTTAGAGGACTTCCAATAAGATACCAAACTCCA GCTATCAGGGCTGAGCACACCGGGCGGGAGATTGTGGACTTAATGTGTCATGCCACATTT ACCATGAGGCTGCTATCACCAATCAGGGTGCCAAATTACAACCTGATCATCATGGACGAA GCCCATTTTACAGATCCAGCAAGCATAGCAGCTAGGGGATACATCTCAACTCGAGTGGAG ATGGGTGAGGCAGCTGGAATTTTTATGACAGCCACTCCTCCGGGTAGCAGAGATCCATTT CCTCAGAGTAATGCACCAATTATGGACGAAGAAAGAGAAATCCCGGAACGTTCATGGAAC TCCGGGCACGAGTGGGTCACGGATTTTAAAGGAAAGACTGTCTGGTTTGTTCCAAGCATA AAAACCGGAAATGACATAGCAGCCTGCCTGAGAAAGAATGGAAAGAGGGTGATACAACTC AGTAGGAAGACCTTTGATTCTGAATATGTCAAGACTAGAACCAATGACTGGGATTTCGTG GTTACAACTGACATCTCGGAAATGGGTGCCAACTTTAAAGCTGAGAGGGTTATAGACCCC AGACGCTGCATGAAACCAGTTATACTGACAGACGGCGAAGAGCGGGTGATTCTGGCAGGA CCCATGCCAGTGACCCACTCTAGTGCAGCACAAAGAAGAGGGAGAATAGGAAGGAATCCA AGGAATGAAAATGATCAATATATATATATGGGGGAACCCCTGGAAAATGATGAAGACTGT GCGCACTGGAAGGAAGCTAAGATGCTCCTAGATAACATCAACACACCTGAAGGAATCATT CCCAGCATGTTCGAGCCAGAGCGTGAAAAGGTGGATGCCATTGACGGTGAATATCGCTTG AGAGGAGAAGCACGGAAAACTTTTGTGGACCTAATGAGAAGAGGAGACCTACCAGTCTGG TTGGCTTATAAAGTGGCTGCTGAAGGTATCAACTACGCAGACAGAAGATGGTGTTTTGAC GGAACCAGAAACAATCAAATCTTGGAAGAAAATGTGGAAGTGGAAATCTGGACAAAGGAA GGGGAAAGGAAAAAATTGAAACCTAGATGGTTAGATGCTAGGATCTACTCCGACCCACTG GCGCTAAAAGAATTCGCAGCCGGAAGAAAGTCCCTAACCCTGAACCTAATCACAGAGATG GGCAGACTCCCAACTTTTATGACTCAGAAGGCCAGAGATGCACTAGACAACTTGGCGGTG CTGCACACGGCTGAAGCGGGTGGAAAGGCATACAATCATGCTCTCAGTGAACTACCGGAG ACCCTGGAGACATTGCTTTTGCTGACACTGTTGGCCACAGTCACGGGAGGAATCTTTCTA TTCCTGATGAGCGGAAGGGGTATAGGGAAGATGACCCTGGGAATGTGCTGCATAATCACG GCCAGCATCCTCTTATGGTATGCACAAATACAACCACATTGGATAGCAGCTTCAATAATA TTGGAGTTCTTTCTCATAGTCTTGCTCATTCCAGAACCAGAAAAGCAGAGGACACCCCAG GATAACCAATTGACTTATGTCATCATAGCCATCCTCACAGTGGTGGCCGCAACCATGGCA AACGAAATGGGTTTTCTGGAAAAAACAAAGAAAGACCTCGGACTGGGAAACATTGCAACT CAGCAACCTGAGAGCAACATTCTGGACATAGATCTACGTCCTGCATCAGCATGGACGTTG TATGCCGTGGCCACAACATTTATCACACCAATGTTGAGACATAGCATTGAAAATTCCTCA GTAAATGTGTCCCTAACAGCCATAGCTAACCAAGCCACAGTGCTAATGGGTCTCGGGAAA GGATGGCCATTGTCAAAGATGGACATTGGAGTTCCCCTCCTTGCTATTGGGTGTTACTCA CAAGTCAACCCTATAACCCTCACAGCGGCTCTTCTTTTATTGGTAGCACATTATGCCATC ATAGGACCGGGACTTCAAGCCAAAGCAACCAGAGAAGCTCAGAAAAGAGCAGCAGCGGGC ATCATGAAAAACCCAACTGTGGATGGAATAACAGTGATAGATCTAGATCCAATACCCTAT GATCCAAAGTTTGAAAAGCAGTTGGGACAAGTAATGCTCCTAGTCCTCTGTGTGACCCAA GTGCTGATGATGAGGACTACGTGGGCTTTGTGTGAAGCCTTAACTCTAGCAACCGGACCC GTGTCCACATTGTGGGAAGGAAATCCAGGGAGATTCTGGAACACAACCATTGCAGTGTCA ATGGCAAACATCTTTAGAGGGAGTTACCTGGCTGGAGCTGGACTTCTCTTTTCTATCATG AAGAACACAACCAGCACGAGAAGAGGAACTGGCAACATAGGAGAAACGCTAGGAGAGAAA TGGAAAAGCAGGCTGAACGCATTGGGGAAAAGTGAATTCCAGATCTATAAAAAAAGTGGA ATTCAAGAAGTGGACAGAACCTTAGCAAAAGAAGGCATTAAAAGAGGAGAAACGGATCAT CACGCTGTGTCGCGAGGCTCAGCAAAACTGAGATGGTTCGTTGAAAGAAATTTGGTCACA CCAGAAGGGAAAGTAGTGGACCTTGGTTGCGGCAGAGGGGGCTGGTCATACTATTGTGGA GGATTAAAGAATGTAAGAGAAGTCAAAGGCTTAACAAAAGGAGGACCAGGACACGAAGAA CCTATCCCTATGTCAACATATGGGTGGAATCTAGTACGCTTACAGAGCGGAGTTGACGTT TTTTTTGTTCCACCAGAGAAGTGTGACACATTGTTGTGTGACATAGGGGAATCATCACCA AATCCCACGGTAGAAGCGGGACGAACACTCAGAGTCCTTAACCTAGTGGAAAATTGGTTG AACAATAACACCCAATTTTGCGTAAAGGTTCTTAACCCGTACATGCCCTCAGTCATTGAA AGAATGGAAACCTTACAACGGAAATACGGAGGAGCCTTGGTGAGAAATCCACTCTCACGG AATTCCACACATGAGATGTACTGGGTGTCCAATGCTTCCGGGAACATAGTGTCATCAGTG AACATGATTTCAAGAATGCTGATTAACAGATTCACCATGAGACACAAGAAGGCCACCTAT GAGCCAGATGTCGACCTCGGAAGCGGAACCCGCAATATTGGAATTGAAAGTGAGACACCG AACCTAGACATAATTGGGAAAAGAATAGAAAAAATAAAACAAGAGCATGAAACGTCATGG CACTATGACCAAGACCACCCATACAAAACATGGGCTTACCATGGCAGCTATGAAACAAAA CAGACTGGATCAGCATCATCCATGGTGAACGGAGTAGTCAGATTGCTGACAAAACCCTGG GACGTTGTTCCAATGGTGACACAGATGGCAATGACAGACACAACTCCTTTCGGACAACAG CGCGTCTTCAAAGAGAAGGTGGATACGAGAACCCAAGAACCAAAAGAAGGCACAAAAAAA CTAATGAAAATCACGGCAGAGTGGCTCTGGAAAGAACTAGGAAAGAAAAAGACACCTAGA ATGTGCACCAGAGAAGAATTCACAAAAAAGGTGAGAAGCAATGCAGCCTTGGGGGCCATA TTTACCGATGAGAACAAGTGGAAATCGGCGCGTGAGGCTGTTGAAGATAGTAGGTTTTGG GAGCTGGTTGACAAGGAAAGAAACCTCCATCTTGAAGGGAAATGTGAAACATGTGTATAC AACATGATGGGAAAAAGAGAGAAAAAACTAGGAGAGTTTGGTAAAGCAAAAGGCAGCAGA GCCATATGGTACATGTGGCTCGGAGCACGCTTCTTAGAGTTCGAAGCCCTAGGATTTTTG AATGAAGACCATTGGTTCTCCAGAGAGAACTCCCTGAGTGGAGTAGAAGGAGAAGGGCTG CATAAGCTAGGTTACATCTTAAGAGAGGTGAGCAAGAAAGAAGGAGGAGCAATGTATGCC GATGACACCGCAGGCTGGGACACAAGAATCACAATAGAGGATTTAAAAAATGAAGAAATG ATAACGAACCACATGGCAGGAGAACACAAGAAACTTGCCGAGGCCATTTTTAAATTGACG TATCAAAACAAGGTGGTGCGTGTGCAAAGACCAACACCAAGAGGCACAGTAATGGACATC ATATCGAGAAGAGACCAAAGGGGTAGTGGACAAGTTGGTACCTATGGCCTCAACACTTTC ACCAACATGGAAGCACAACTAATTAGGCAAATGGAGGGGGAAGGAATCTTCAAAAGCATC CAGCACTTGACAGCCTCAGAAGAAATCGCTGTGCAAGATTGGCTAGCAAGAGTAGGGCGT GAAAGGTTGTCAAGAATGGCCATCAGTGGAGATGATTGTGTTGTGAAACCTTTAGATGAT AGATTTGCAAGAGCTCTAACAGCTCTAAATGACATGGGAAAGGTTAGGAAGGACATACAG CAATGGGAGCCCTCAAGAGGATGGAACGACTGGACACAGGTACCCTTCTGTTCACACCAT TTTCACGAGTTAATTATGAAAGATGGTCGCACACTCGTAGTTCCATGCAGAAACCAAGAT GAATTGATCGGCAGAGCCCGAATTTCCCAGGGAGCTGGGTGGTCTTTACGGGAGACGGCC TGTTTGGGGAAGTCTTACGCCCAAATGTGGAGCTTGATGTACTTCCACAGACGTGATCTC AGGCTAGCGGCAAATGCCATCTGCTCGGCAGTCCCGTCACACTGGGTTCCAACAAGCCGG ACAACCTGGTCCATACACGCCAGCCATGAATGGATGACGACGGAAGACATGTTGACAGTT TGGAACAAAGTGTGGATCCTAGAAAATCCATGGATGGAAGACAAAACTCCAGTGGAATCA TGGGAGGAAATCCCATACCTGGGAAAAAGAGAAGACCAATGGTGCGGCTCACTGATTGGG CTGACAAGCAGAGCCACCTGGGCGAAGAATATCCAGACAGCAATAAACCAAGTCAGATCC CTCATTGGCAATGAGGAATACACAGATTACATGCCATCCATGAAAAGATTCAGAAGAGAA GAGGAAGAGGCAGGAGTTTTGTGGTAG PF01003 Flavi_capsid PF07652 Flavi_DEAD PF02832 Flavi_glycop_C PF00869 Flavi_glycoprot PF01004 Flavi_M PF00948 Flavi_NS1 PF01005 Flavi_NS2A PF01002 Flavi_NS2B PF01350 Flavi_NS4A PF01349 Flavi_NS4B PF00972 Flavi_NS5 PF01570 Flavi_propep PF01728 FtsJ PF00949 Peptidase_S7 component virion component viral envelope component viral capsid component cell component intrinsic to membrane component integral to membrane component membrane function catalytic activity function transferase activity, transferring phosphorus-containing groups function hydrolase activity function nucleic acid binding function nucleotide binding function RNA binding function purine nucleotide binding function structural molecule activity function helicase activity function adenyl nucleotide binding function peptidase activity function ATP-dependent helicase activity function transferase activity function endopeptidase activity function serine-type endopeptidase activity function RNA helicase activity function nucleotidyltransferase activity function double-stranded RNA binding function RNA-directed RNA polymerase activity function binding function ATP binding process viral infectious cycle process viral genome replication process viral life cycle BE0000722 Inosine-5'-monophosphate dehydrogenase 2 Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Inosine-5'-monophosphate dehydrogenase 2 Nucleotide transport and metabolism Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors IMPDH2 3p21.2 None 6.9 55806.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:6053 GenAtlas IMPDH2 GeneCards IMPDH2 GenBank Gene Database J04208 GenBank Protein Database 307066 UniProtKB P12268 UniProt Accession IMDH2_HUMAN EC 1.1.1.205 IMP dehydrogenase 2 IMPD 2 IMPDH-II >Inosine-5'-monophosphate dehydrogenase 2 MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF >1545 bp ATGGCCGACTACCTGATTAGTGGGGGCACGTCCTACGTGCCAGACGACGGACTCACAGCA CAGCAGCTCTTCAACTGCGGAGACGGCCTCACCTACAATGACTTTCTCATTCTCCCTGGG TACATCGACTTCACTGCAGACCAGGTGGACCTGACTTCTGCTCTGACCAAGAAAATCACT CTTAAGACCCCACTGGTTTCCTCTCCCATGGACACAGTCACAGAGGCTGGGATGGCCATA GCAATGGCGCTTACAGGCGGTATTGGCTTCATCCACCACAACTGTACACCTGAATTCCAG GCCAATGAAGTTCGGAAAGTGAAGAAATATGAACAGGGATTCATCACAGACCCTGTGGTC CTCAGCCCCAAGGATCGCGTGCGGGATGTTTTTGAGGCCAAGGCCCGGCATGGTTTCTGC GGTATCCCAATCACAGACACAGGCCGGATGGGGAGCCGCTTGGTGGGCATCATCTCCTCC AGGGACATTGATTTTCTCAAAGAGGAGGAACATGACTGTTTCTTGGAAGAGATAATGACA AAGAGGGAAGACTTGGTGGTAGCCCCCCGCAGCATCACACTGAAGGAGGCAAATGAAATT CTGCAGCGCAGCAAGAAGGGAAAGTTGCCCATTGTAAATGAAGATGATGAGCTTGTGGCC ATCATTGCCCGGACAGACCTGAAGAAGAATCGGGACTACCCACTAGCCTCCAAAGATGCC AAGAAACAGCTGCTGTGTGGGGCAGCCATTGGCACTCATGAGGATGACAAGTATAGGCTG GACTTGCTCGCCCAGGCTGGTGTGGATGTAGTGGTTTTGGACTCTTCCCAGGGAAATTCC ATCTTCCAGATCAATATGATCAAGTACATCAAAGACAAATACCCTAATCTCCAAGTCATT GGAGGCAATGTGGTCACTGCTGCCCAGGCCAAGAACCTCATTGATGCAGGTGTGGATGCC CTGCGGGTGGGCATGGGAAGTGGCTCCATCTGCATTACGCAGGAAGTGCTGGCCTGTGGG CGGCCCCAAGCAACAGCAGTGTACAAGGTGTCAGAGTATGCACGGCGCTTTGGTGTTCCG GTCATTGCTGATGGAGGAATCCAAAATGTGGGTCATATTGCGAAAGCCTTGGCCCTTGGG GCCTCCACAGTCATGATGGGCTCTCTCCTGGCTGCCACCACTGAGGCCCCTGGTGAATAC TTCTTTTCCGATGGGATCCGGCTAAAGAAATATCGCGGTATGGGTTCTCTCGATGCCATG GACAAGCACCTCAGCAGCCAGAACAGATATTTCAGTGAAGCTGACAAAATCAAAGTGGCC CAGGGAGTGTCTGGTGCTGTGCAGGACAAAGGGTCAATCCACAAATTTGTCCCTTACCTG ATTGCTGGCATCCAACACTCATGCCAGGACATTGGTGCCAAGAGCTTGACCCAAGTCCGA GCCATGATGTACTCTGGGGAGCTTAAGTTTGAGAAGAGAACGTCCTCAGCCCAGGTGGAA GGTGGCGTCCATAGCCTCCATTCGTATGAGAAGCGGCTTTTCTGA PF00571 CBS PF00478 IMPDH function catalytic activity function IMP dehydrogenase activity function oxidoreductase activity function oxidoreductase activity, acting on CH-OH group of donors function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor process purine ribonucleoside monophosphate biosynthesis process physiological process process GMP biosynthesis process purine nucleotide metabolism process metabolism process purine nucleotide biosynthesis process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process nucleotide metabolism process purine nucleoside monophosphate biosynthesis "
drugbank:interactsWith	drug:Abacavir
owl:sameAs	drug:Abacavir drug:EXPT02825

"Ribavirin Monophosphate"

" 40925-28-8 experimental This compound belongs to the triazole ribonucleosides and ribonucleotides. These are nucleoside derivatives containing a ribose derivative which is n-glycosylated to a triazole. Triazole Ribonucleosides and Ribonucleotides Organic Compounds Organooxygen Compounds Carbohydrates and Carbohydrate Conjugates Glycosyl Compounds Pentose Phosphates Monosaccharide Phosphates Triazole Carboxamides Organophosphate Esters Organic Phosphoric Acids Oxolanes Tetrahydrofurans 1,2-Diols Secondary Alcohols Primary Carboxylic Acid Amides Ethers Enolates Carboxylic Acids Polyamines monosaccharide phosphate pentose monosaccharide 1,2,4-triazole carboxamide 1,2,4-triazole carboxylic acid or derivative phosphoric acid ester organic phosphate monosaccharide oxolane azole tetrahydrofuran 1,2,4-triazole carboxamide group primary carboxylic acid amide 1,2-diol secondary alcohol enolate carboxylic acid derivative polyamine carboxylic acid ether organonitrogen compound amine alcohol DB01048 Abacavir Ribavirin Monophosphate may increase the hepatotoxicity of reverse transcriptase inhibitors (nucleoside) such as Abacavir. Lactic acidosis may occur. Consider modifying therapy. logP -2.7 ALOGPS logS -2 ALOGPS Water Solubility 3.34e+00 g/l ALOGPS logP -2.9 ChemAxon IUPAC Name {[(2S,3R,4R,5R)-5-(3-carbamoyl-1H-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid ChemAxon Traditional IUPAC Name [(2S,3R,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxyphosphonic acid ChemAxon Molecular Weight 324.1846 ChemAxon Monoisotopic Weight 324.047099924 ChemAxon SMILES NC(=O)C1=NN(C=N1)[C@@H]1O[C@@H](COP(O)(O)=O)[C@H](O)[C@H]1O ChemAxon Molecular Formula C8H13N4O8P ChemAxon InChI InChI=1S/C8H13N4O8P/c9-6(15)7-10-2-12(11-7)8-5(14)4(13)3(20-8)1-19-21(16,17)18/h2-5,8,13-14H,1H2,(H2,9,15)(H2,16,17,18)/t3-,4-,5+,8+/m0/s1 ChemAxon InChIKey InChIKey=SDWIOXKHTFOULX-PDNLFSCWSA-N ChemAxon Polar Surface Area (PSA) 190.25 ChemAxon Refractivity 75.45 ChemAxon Polarizability 26.6 ChemAxon Rotatable Bond Count 5 ChemAxon H Bond Acceptor Count 9 ChemAxon H Bond Donor Count 5 ChemAxon pKa (strongest acidic) 1.23 ChemAxon pKa (strongest basic) -1.2 ChemAxon Physiological Charge -2 ChemAxon Number of Rings 2 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon PubChem Compound 5748447 PubChem Substance 46504726 ChemSpider 284811 PDB RVP BE0001261 Genome polyprotein DENV-2 # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Genome polyprotein Involved in nucleic acid binding The small proteins NS2A, NS4A and NS4B are hydrophobic, suggesting a possible membrane-related function. NS5 may play a role in the viral RNA replication. The NS2B/NS3 protease complex processes the viral polyprotein Cytoplasmic 43-59 101-117 268-284 727-743 757-773 8.67 379224.0 DENV-2 GenBank Gene Database M19197 GenBank Protein Database 323655 UniProtKB P12823 UniProt Accession POLG_DEN2P Core protein EC 2.7.7.48 EC 3.4.21.91 Envelope protein M Flavivirin protease NS2B regulatory subunit Flavivirin protease NS3 catalytic subunit Genome polyprotein [Contains: Capsid protein C Major envelope protein E Matrix protein Non- structural protein 1 Non-structural protein 2A Non-structural protein 4A Non-structural protein 4B NS1 NS2A NS4A NS4B NS5] RNA-directed RNA polymerase >Genome polyprotein [Contains: Capsid protein C MNDQRKKARNTPFNMLKRERNRVSTVQQLTKRFSLGMLQGRGPLKLFMALVAFLRFLTIP PTAGILKRWGTIKKSKAINVLRGFRKEIGRMLNILNRRRRTAGMIIMLIPTVMAFHLTTR NGEPHMIVSRQEKGKSLLFKTKDGTNMCTLMAMDLGELCEDTITYKCPFLKQNEPEDIDC WCNSTSTWVTYGTCTTTGEHRREKRSVALVPHVGMGLETRTETWMSSEGAWKHAQRIETW ILRHPGFTIMAAILAYTIGTTHFQRVLIFILLTAIAPSMTMRCIGISNRDFVEGVSGGSW VDIVLEHGSCVTTMAKNKPTLDFELIKTEAKQPATLRKYCIEAKLTNTTTDSRCPTQGEP TLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKIVQPENLEYTVV ITPHSGEEHAVGNDTGKHGKEVKITPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQ MKDKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAM HTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTI VIRVQYEGDGSPCKTPFEIMDLEKRHVLGRLTTVNPIVTEKDSPVNIEAEPPFGDSYIII GVEPGQLKLDWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVF GAIYGAAFSGVSWTMKILIGVIITWIGMNSRSTSLSVSLVLVGIVTLYLGVMVQADSGCV VSWKNKELKCGSGIFVTDNVHTWTEQYKFQPESPSKLASAIQKAHEEGICGIRSVTRLEN LMWKQITSELNHILSENEVKLTIMTGDIKGIMQVGKRSLRPQPTELRYSWKTWGKAKMLS TELHNQTFLIDGPETAECPNTNRAWNSLEVEDYGFGVFTTNIWLRLREKQDAFCDSKLMS AAIKDNRAVHADMGYWIESALNDTWKIEKASFIEVKSCHWPKSHTLWSNGVLESEMVIPK NFAGPVSQHNNRPGYHTQTAGPWHLGKLEMDFDFCEGTTVVVTEDCGNRGPSLRTTTASG KLITEWCCRSCTLPPLRYRGEDGCWYGMEIRPLKEKEENLVSSLVTAGHGQIDNFSLGIL GMALFLEEMLRTRVGTKHAILLVAVSFVTLITGNMSFRDLGRVMVMVGATMTDDIGMGVT YLALLAAFKVRPTFAAGLLLRKLTSKELMMTTIGIVLLSQSSIPETILELTDALALGMMV LKMVRNMEKYQLAVTIMAILCVPNAVILQNAWKVSCTILAVVSVSPLFLTSSQQKADWIP LALTIKGLNPTAIFLTTLSRTSKKRSWPLNEAIMAVGMVSILASSLLKNDTPMTGPLVAG GLLTVCYVLTGRSADLELERATDVKWDDQAEISGSSPILSITISEDGSMSIKNEEEEQTL TILIRTGLLVISGLFPVSIPITAAAWYLWEVKKQRAGVLWDVPSPPPVGKAELEDGAYRI KQKGILGYSQIGAGVYKEGTFHTMWHVTRGAVLMHKGKRIEPSWADVKKDLISYGGGWKL EGEWKEGEEVQVLALEPGKNPRAVQTKPGLFRTNTGTIGAVSLDFSPGTSGSPIVDKKGK VVGLYGNGVVTRSGAYVSAIAQTEKSIEDNPEIEDDIFRKRRLTIMDLHPGAGKTKRYLP AIVREAIKRGLRTLILAPTRVVAAEMEEALRGLPIRYQTPAIRAEHTGREIVDLMCHATF TMRLLSPIRVPNYNLIIMDEAHFTDPASIAARGYISTRVEMGEAAGIFMTATPPGSRDPF PQSNAPIMDEEREIPERSWNSGHEWVTDFKGKTVWFVPSIKTGNDIAACLRKNGKRVIQL SRKTFDSEYVKTRTNDWDFVVTTDISEMGANFKAERVIDPRRCMKPVILTDGEERVILAG PMPVTHSSAAQRRGRIGRNPRNENDQYIYMGEPLENDEDCAHWKEAKMLLDNINTPEGII PSMFEPEREKVDAIDGEYRLRGEARKTFVDLMRRGDLPVWLAYKVAAEGINYADRRWCFD GTRNNQILEENVEVEIWTKEGERKKLKPRWLDARIYSDPLALKEFAAGRKSLTLNLITEM GRLPTFMTQKARDALDNLAVLHTAEAGGKAYNHALSELPETLETLLLLTLLATVTGGIFL FLMSGRGIGKMTLGMCCIITASILLWYAQIQPHWIAASIILEFFLIVLLIPEPEKQRTPQ DNQLTYVIIAILTVVAATMANEMGFLEKTKKDLGLGNIATQQPESNILDIDLRPASAWTL YAVATTFITPMLRHSIENSSVNVSLTAIANQATVLMGLGKGWPLSKMDIGVPLLAIGCYS QVNPITLTAALLLLVAHYAIIGPGLQAKATREAQKRAAAGIMKNPTVDGITVIDLDPIPY DPKFEKQLGQVMLLVLCVTQVLMMRTTWALCEALTLATGPVSTLWEGNPGRFWNTTIAVS MANIFRGSYLAGAGLLFSIMKNTTSTRRGTGNIGETLGEKWKSRLNALGKSEFQIYKKSG IQEVDRTLAKEGIKRGETDHHAVSRGSAKLRWFVERNLVTPEGKVVDLGCGRGGWSYYCG GLKNVREVKGLTKGGPGHEEPIPMSTYGWNLVRLQSGVDVFFVPPEKCDTLLCDIGESSP NPTVEAGRTLRVLNLVENWLNNNTQFCVKVLNPYMPSVIERMETLQRKYGGALVRNPLSR NSTHEMYWVSNASGNIVSSVNMISRMLINRFTMRHKKATYEPDVDLGSGTRNIGIESETP NLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPW DVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPR MCTREEFTKKVRSNAALGAIFTDENKWKSAREAVEDSRFWELVDKERNLHLEGKCETCVY NMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGL HKLGYILREVSKKEGGAMYADDTAGWDTRITIEDLKNEEMITNHMAGEHKKLAEAIFKLT YQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGIFKSI QHLTASEEIAVQDWLARVGRERLSRMAISGDDCVVKPLDDRFARALTALNDMGKVRKDIQ QWEPSRGWNDWTQVPFCSHHFHELIMKDGRTLVVPCRNQDELIGRARISQGAGWSLRETA CLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHASHEWMTTEDMLTV WNKVWILENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRS LIGNEEYTDYMPSMKRFRREEEEAGVLW >10167 bp ATGAATGACCAACGGAAAAAGGCGAGAAACACGCCTTTCAATATGCTGAAACGCGAGAGA AACCGCGTGTCAACTGTACAACAGTTGACAAAGAGATTCTCACTTGGAATGCTGCAGGGA CGAGGACCACTAAAATTGTTCATGGCCCTGGTGGCATTCCTTCGTTTCCTAACAATCCCA CCAACAGCAGGGATATTAAAAAGATGGGGAACAATTAAAAAATCAAAGGCTATTAATGTT CTGAGAGGCTTCAGGAAAGAGATTGGAAGGATGCTGAATATCTTAAACAGGAGACGTAGA ACTGCAGGCATGATCATCATGCTGATTCCAACAGTGATGGCGTTTCATCTGACCACACGC AACGGAGAACCACACATGATCGTCAGTAGACAAGAAAAAGGGAAAAGCCTTCTGTTTAAG ACAAAGGACGGCACGAACATGTGTACCCTCATGGCCATGGACCTTGGTGAGTTGTGTGAA GACACAATCACGTATAAATGTCCCTTTCTCAAGCAGAACGAACCAGAAGACATAGATTGT TGGTGCAACTCCACGTCCACATGGGTAACTTATGGGACATGTACCACCACAGGAGAGCAC AGAAGAGAAAAAAGATCAGTGGCGCTTGTTCCACACGTGGGAATGGGATTGGAGACACGA ACTGAAACATGGATGTCATCAGAAGGGGCCTGGAAACATGCCCAGAGAATTGAAACTTGG ATTCTGAGACATCCAGGCTTTACCATAATGGCCGCAATCCTGGCATACACCATAGGAACG ACGCATTTCCAAAGAGTCCTGATATTCATCCTACTGACAGCCATCGCTCCTTCAATGACA ATGCGCTGCATAGGAATATCAAATAGGGACTTTGTGGAAGGAGTGTCAGGAGGGAGTTGG GTTGACATAGTTTTAGAACATGGAAGTTGTGTGACGACGATGGCAAAAAATAAACCAACA CTGGACTTTGAACTGATAAAAACAGAAGCCAAACAACCCGCCACCTTAAGGAAGTACTGT ATAGAGGCTAAACTGACCAACACGACAACAGACTCGCGCTGCCCAACACAAGGGGAACCC ACCCTGAATGAAGAGCAGGACAAAAGGTTTGTCTGCAAACATTCCATGGTAGACAGAGGA TGGGGAAATGGATGTGGATTATTTGGAAAAGGAGGCATCGTGACCTGTGCCATGTTCACA TGCAAAAAGAACATGGAGGGAAAAATTGTGCAGCCAGAAAACCTGGAATACACTGTCGTT ATAACACCTCATTCAGGGGAAGAACATGCAGTCGGAAATGACACAGGAAAACATGGTAAA GAAGTCAAGATAACACCACAGAGCTCCATCACAGAGGCGGAACTGACAGGCTATGGCACT GTTACGATGGAGTGCTCTCCAAGAACGGGCCTCGACTTCAATGAGATGGTGTTGCTGCAA ATGAAAGACAAAGCTTGGCTGGTGCACAGACAATGGTTCCTAGACCTACCGTTGCCATGG CTGCCCGGAGCAGACACACAAGGATCAAATTGGATACAGAAAGAGACACTGGTCACCTTC AAAAATCCCCATGCGAAAAAACAGGATGTTGTTGTCTTAGGATCCCAAGAGGGGGCCATG CATACAGCACTCACAGGGGCTACGGAAATCCAGATGTCATCAGGAAACCTGCTGTTCACA GGACATCTTAAGTGCAGGCTGAGAATGGACAAATTACAACTTAAAGGGATGTCATACTCC ATGTGCACAGGAAAGTTTAAAGTTGTGAAGGAAATAGCAGAAACACAACATGGAACAATA GTCATTAGAGTACAATATGAAGGAGACGGCTCTCCATGCAAGACCCCTTTTGAGATAATG GATCTGGAAAAAAGACATGTTTTGGGCCGCCTGACCACAGTCAACCCAATTGTAACAGAA AAGGACAGTCCAGTCAACATAGAAGCAGAACCTCCATTCGGAGACAGCTACATCATCATA GGAGTGGAACCAGGACAATTGAAGCTGGACTGGTTCAAGAAAGGAAGTTCCATCGGCCAA ATGTTTGAGACAACAATGAGGGGAGCGAAAAGAATGGCCATTTTGGGCGACACAGCCTGG GATTTTGGATCTCTGGGAGGAGTGTTCACATCAATAGGAAAGGCTCTCCACCAGGTTTTT GGAGCAATCTACGGGGCTGCTTTCAGTGGGGTCTCATGGACTATGAAGATCCTCATAGGA GTTATCATCACATGGATAGGAATGAACTCACGTAGCACATCACTGTCTGTGTCACTGGTA TTAGTGGGAATCGTGACACTGTACTTGGGAGTTATGGTGCAGGCCGATAGTGGTTGCGTT GTGAGCTGGAAGAACAAAGAACTAAAATGTGGCAGTGGAATATTCGTCACAGATAACGTG CATACATGGACAGAACAATACAAGTTCCAACCAGAATCCCCTTCAAAACTGGCTTCAGCC ATCCAGAAAGCTCATGAAGAGGGCATCTGTGGAATCCGCTCAGTAACAAGACTGGAAAAT CTTATGTGGAAACAAATAACATCAGAATTGAATCATATTCTATCAGAAAATGAAGTGAAA CTGACCATCATGACAGGAGACATCAAAGGAATCATGCAGGTAGGAAAACGATCTCTGCGG CCTCAACCCACTGAGTTGAGGTATTCATGGAAAACATGGGGTAAAGCGAAAATGCTCTCC ACAGAACTCCATAATCAGACCTTCCTCATTGATGGTCCCGAAACAGCAGAATGCCCCAAC ACAAACAGAGCTTGGAATTCACTAGAAGTTGAGGACTACGGCTTTGGAGTATTCACTACC AATATATGGCTAAGATTGAGAGAAAAGCAGGATGCATTTTGTGACTCAAAACTCATGTCA GCGGCCATAAAGGACAACAGAGCCGTCCATGCTGATATGGGTTATTGGATAGAAAGCGCA CTCAATGATACATGGAAGATAGAGAAAGCTTCTTTCATTGAAGTCAAAAGTTGCCACTGG CCAAAGTCACACACTCTATGGAGTAATGGAGTGCTAGAAAGCGAGATGGTAATTCCAAAG AATTTCGCTGGACCAGTGTCACAACATAATAACAGACCAGGCTATCACACACAAACAGCA GGACCTTGGCATCTAGGCAAGCTTGAGATGGACTTTGATTTCTGCGAAGGGACTACAGTG GTGGTAACCGAGGACTGTGGAAACAGAGGGCCCTCTTTAAGAACAACCACTGCCTCAGGA AAACTCATAACGGAATGGTGTTGTCGATCTTGCACACTACCACCACTAAGATACAGAGGT GAGGATGGATGCTGGTACGGGATGGAAATCAGACCATTGAAAGAGAAAGAAGAAAATCTG GTCAGTTCTCTGGTCACAGCCGGACATGGGCAGATTGATAATTTCTCATTAGGAATCTTG GGAATGGCACTGTTCCTTGAAGAAATGCTCAGGACTCGAGTAGGAACGAAACATGCAATA TTACTAGTCGCAGTTTCTTTCGTAACGTTAATCACAGGGAACATGTCTTTTAGAGACCTG GGAAGAGTGATGGTTATGGTGGGTGCCACCATGACAGATGACATAGGCATGGGTGTGACT TATCTTGCTCTACTAGCAGCTTTCAAAGTCAGACCAACCTTTGCAGCTGGACTGCTCTTG AGAAAACTGACCTCCAAGGAATTAATGATGACCACCATAGGAATCGTTCTTCTCTCCCAG AGTAGCATACCAGAGACCATTCTTGAACTGACCGATGCGTTAGCTTTAGGCATGATGGTC CTCAAGATGGTGAGAAACATGGAAAAATATCAGCTGGCAGTGACCATCATGGCTATTTTG TGCGTCCCAAATGCTGTGATATTACAGAACGCATGGAAAGTGAGTTGCACAATATTGGCA GTGGTGTCTGTTTCCCCCCTGTTCTTAACATCCTCACAACAGAAAGCGGACTGGATACCA TTAGCGTTGACGATCAAAGGCCTCAATCCAACAGCCATTTTTCTAACAACCCTCTCAAGA ACCAGCAAGAAAAGGAGCTGGCCTTTAAATGAGGCCATCATGGCGGTTGGGATGGTGAGT ATCTTGGCCAGCTCTCTCTTAAAGAATGACACCCCCATGACAGGACCATTAGTGGCTGGA GGGCTTCTTACTGTGTGCTACGTACTAACTGGGCGGTCAGCCGATCTGGAACTAGAGAGA GCTACCGATGTCAAATGGGATGACCAGGCAGAGATATCAGGTAGCAGTCCAATTCTGTCA ATAACAATATCAGAAGATGGCAGCATGTCAATAAAGAATGAAGAGGAAGAGCAAACATTG ACTATACTCATTAGAACAGGATTGCTTGTGATCTCAGGACTCTTTCCGGTATCAATACCA ATTACAGCAGCAGCATGGTACCTGTGGGAAGTAAAGAAACAACGGGCTGGAGTGTTGTGG GATGTCCCCTCACCACCACCCGTGGGAAAGGCTGAATTGGAAGATGGAGCCTACAGAATC AAGCAAAAAGGAATCCTTGGATATTCCCAGATCGGAGCTGGAGTTTACAAAGAAGGAACA TTTCACACAATGTGGCACGTCACACGTGGCGCTGTCCTAATGCATAAGGGGAAGAGGATT GAACCATCATGGGCGGACGTCAAGAAAGACTTAATATCATATGGAGGAGGTTGGAAGCTA GAAGGAGAATGGAAAGAAGGAGAAGAAGTCCAGGTCTTGGCATTGGAGCCTGGGAAAAAT CCAAGAGCCGTCCAAACAAAACCTGGCCTTTTTAGAACCAATACTGGAACCATAGGTGCC GTATCTCTGGACTTTTCCCCTGGGACGTCAGGATCTCCAATCGTCGACAAAAAAGGAAAA GTTGTAGGCCTCTATGGCAATGGTGTCGTTACAAGGAGTGGAGCATATGTGAGTGCCATA GCTCAGACTGAAAAAAGCATTGAAGACAATCCAGAGATTGAAGATGACATCTTTCGAAAG AGAAGATTGACTATCATGGATCTCCACCCAGGAGCAGGAAAGACAAAGAGATACCTCCCG GCCATAGTCAGAGAGGCCATAAAAAGAGGCTTGAGAACACTAATCCTAGCCCCCACTAGA GTCGTGGCAGCTGAAATGGAGGAAGCCCTTAGAGGACTTCCAATAAGATACCAAACTCCA GCTATCAGGGCTGAGCACACCGGGCGGGAGATTGTGGACTTAATGTGTCATGCCACATTT ACCATGAGGCTGCTATCACCAATCAGGGTGCCAAATTACAACCTGATCATCATGGACGAA GCCCATTTTACAGATCCAGCAAGCATAGCAGCTAGGGGATACATCTCAACTCGAGTGGAG ATGGGTGAGGCAGCTGGAATTTTTATGACAGCCACTCCTCCGGGTAGCAGAGATCCATTT CCTCAGAGTAATGCACCAATTATGGACGAAGAAAGAGAAATCCCGGAACGTTCATGGAAC TCCGGGCACGAGTGGGTCACGGATTTTAAAGGAAAGACTGTCTGGTTTGTTCCAAGCATA AAAACCGGAAATGACATAGCAGCCTGCCTGAGAAAGAATGGAAAGAGGGTGATACAACTC AGTAGGAAGACCTTTGATTCTGAATATGTCAAGACTAGAACCAATGACTGGGATTTCGTG GTTACAACTGACATCTCGGAAATGGGTGCCAACTTTAAAGCTGAGAGGGTTATAGACCCC AGACGCTGCATGAAACCAGTTATACTGACAGACGGCGAAGAGCGGGTGATTCTGGCAGGA CCCATGCCAGTGACCCACTCTAGTGCAGCACAAAGAAGAGGGAGAATAGGAAGGAATCCA AGGAATGAAAATGATCAATATATATATATGGGGGAACCCCTGGAAAATGATGAAGACTGT GCGCACTGGAAGGAAGCTAAGATGCTCCTAGATAACATCAACACACCTGAAGGAATCATT CCCAGCATGTTCGAGCCAGAGCGTGAAAAGGTGGATGCCATTGACGGTGAATATCGCTTG AGAGGAGAAGCACGGAAAACTTTTGTGGACCTAATGAGAAGAGGAGACCTACCAGTCTGG TTGGCTTATAAAGTGGCTGCTGAAGGTATCAACTACGCAGACAGAAGATGGTGTTTTGAC GGAACCAGAAACAATCAAATCTTGGAAGAAAATGTGGAAGTGGAAATCTGGACAAAGGAA GGGGAAAGGAAAAAATTGAAACCTAGATGGTTAGATGCTAGGATCTACTCCGACCCACTG GCGCTAAAAGAATTCGCAGCCGGAAGAAAGTCCCTAACCCTGAACCTAATCACAGAGATG GGCAGACTCCCAACTTTTATGACTCAGAAGGCCAGAGATGCACTAGACAACTTGGCGGTG CTGCACACGGCTGAAGCGGGTGGAAAGGCATACAATCATGCTCTCAGTGAACTACCGGAG ACCCTGGAGACATTGCTTTTGCTGACACTGTTGGCCACAGTCACGGGAGGAATCTTTCTA TTCCTGATGAGCGGAAGGGGTATAGGGAAGATGACCCTGGGAATGTGCTGCATAATCACG GCCAGCATCCTCTTATGGTATGCACAAATACAACCACATTGGATAGCAGCTTCAATAATA TTGGAGTTCTTTCTCATAGTCTTGCTCATTCCAGAACCAGAAAAGCAGAGGACACCCCAG GATAACCAATTGACTTATGTCATCATAGCCATCCTCACAGTGGTGGCCGCAACCATGGCA AACGAAATGGGTTTTCTGGAAAAAACAAAGAAAGACCTCGGACTGGGAAACATTGCAACT CAGCAACCTGAGAGCAACATTCTGGACATAGATCTACGTCCTGCATCAGCATGGACGTTG TATGCCGTGGCCACAACATTTATCACACCAATGTTGAGACATAGCATTGAAAATTCCTCA GTAAATGTGTCCCTAACAGCCATAGCTAACCAAGCCACAGTGCTAATGGGTCTCGGGAAA GGATGGCCATTGTCAAAGATGGACATTGGAGTTCCCCTCCTTGCTATTGGGTGTTACTCA CAAGTCAACCCTATAACCCTCACAGCGGCTCTTCTTTTATTGGTAGCACATTATGCCATC ATAGGACCGGGACTTCAAGCCAAAGCAACCAGAGAAGCTCAGAAAAGAGCAGCAGCGGGC ATCATGAAAAACCCAACTGTGGATGGAATAACAGTGATAGATCTAGATCCAATACCCTAT GATCCAAAGTTTGAAAAGCAGTTGGGACAAGTAATGCTCCTAGTCCTCTGTGTGACCCAA GTGCTGATGATGAGGACTACGTGGGCTTTGTGTGAAGCCTTAACTCTAGCAACCGGACCC GTGTCCACATTGTGGGAAGGAAATCCAGGGAGATTCTGGAACACAACCATTGCAGTGTCA ATGGCAAACATCTTTAGAGGGAGTTACCTGGCTGGAGCTGGACTTCTCTTTTCTATCATG AAGAACACAACCAGCACGAGAAGAGGAACTGGCAACATAGGAGAAACGCTAGGAGAGAAA TGGAAAAGCAGGCTGAACGCATTGGGGAAAAGTGAATTCCAGATCTATAAAAAAAGTGGA ATTCAAGAAGTGGACAGAACCTTAGCAAAAGAAGGCATTAAAAGAGGAGAAACGGATCAT CACGCTGTGTCGCGAGGCTCAGCAAAACTGAGATGGTTCGTTGAAAGAAATTTGGTCACA CCAGAAGGGAAAGTAGTGGACCTTGGTTGCGGCAGAGGGGGCTGGTCATACTATTGTGGA GGATTAAAGAATGTAAGAGAAGTCAAAGGCTTAACAAAAGGAGGACCAGGACACGAAGAA CCTATCCCTATGTCAACATATGGGTGGAATCTAGTACGCTTACAGAGCGGAGTTGACGTT TTTTTTGTTCCACCAGAGAAGTGTGACACATTGTTGTGTGACATAGGGGAATCATCACCA AATCCCACGGTAGAAGCGGGACGAACACTCAGAGTCCTTAACCTAGTGGAAAATTGGTTG AACAATAACACCCAATTTTGCGTAAAGGTTCTTAACCCGTACATGCCCTCAGTCATTGAA AGAATGGAAACCTTACAACGGAAATACGGAGGAGCCTTGGTGAGAAATCCACTCTCACGG AATTCCACACATGAGATGTACTGGGTGTCCAATGCTTCCGGGAACATAGTGTCATCAGTG AACATGATTTCAAGAATGCTGATTAACAGATTCACCATGAGACACAAGAAGGCCACCTAT GAGCCAGATGTCGACCTCGGAAGCGGAACCCGCAATATTGGAATTGAAAGTGAGACACCG AACCTAGACATAATTGGGAAAAGAATAGAAAAAATAAAACAAGAGCATGAAACGTCATGG CACTATGACCAAGACCACCCATACAAAACATGGGCTTACCATGGCAGCTATGAAACAAAA CAGACTGGATCAGCATCATCCATGGTGAACGGAGTAGTCAGATTGCTGACAAAACCCTGG GACGTTGTTCCAATGGTGACACAGATGGCAATGACAGACACAACTCCTTTCGGACAACAG CGCGTCTTCAAAGAGAAGGTGGATACGAGAACCCAAGAACCAAAAGAAGGCACAAAAAAA CTAATGAAAATCACGGCAGAGTGGCTCTGGAAAGAACTAGGAAAGAAAAAGACACCTAGA ATGTGCACCAGAGAAGAATTCACAAAAAAGGTGAGAAGCAATGCAGCCTTGGGGGCCATA TTTACCGATGAGAACAAGTGGAAATCGGCGCGTGAGGCTGTTGAAGATAGTAGGTTTTGG GAGCTGGTTGACAAGGAAAGAAACCTCCATCTTGAAGGGAAATGTGAAACATGTGTATAC AACATGATGGGAAAAAGAGAGAAAAAACTAGGAGAGTTTGGTAAAGCAAAAGGCAGCAGA GCCATATGGTACATGTGGCTCGGAGCACGCTTCTTAGAGTTCGAAGCCCTAGGATTTTTG AATGAAGACCATTGGTTCTCCAGAGAGAACTCCCTGAGTGGAGTAGAAGGAGAAGGGCTG CATAAGCTAGGTTACATCTTAAGAGAGGTGAGCAAGAAAGAAGGAGGAGCAATGTATGCC GATGACACCGCAGGCTGGGACACAAGAATCACAATAGAGGATTTAAAAAATGAAGAAATG ATAACGAACCACATGGCAGGAGAACACAAGAAACTTGCCGAGGCCATTTTTAAATTGACG TATCAAAACAAGGTGGTGCGTGTGCAAAGACCAACACCAAGAGGCACAGTAATGGACATC ATATCGAGAAGAGACCAAAGGGGTAGTGGACAAGTTGGTACCTATGGCCTCAACACTTTC ACCAACATGGAAGCACAACTAATTAGGCAAATGGAGGGGGAAGGAATCTTCAAAAGCATC CAGCACTTGACAGCCTCAGAAGAAATCGCTGTGCAAGATTGGCTAGCAAGAGTAGGGCGT GAAAGGTTGTCAAGAATGGCCATCAGTGGAGATGATTGTGTTGTGAAACCTTTAGATGAT AGATTTGCAAGAGCTCTAACAGCTCTAAATGACATGGGAAAGGTTAGGAAGGACATACAG CAATGGGAGCCCTCAAGAGGATGGAACGACTGGACACAGGTACCCTTCTGTTCACACCAT TTTCACGAGTTAATTATGAAAGATGGTCGCACACTCGTAGTTCCATGCAGAAACCAAGAT GAATTGATCGGCAGAGCCCGAATTTCCCAGGGAGCTGGGTGGTCTTTACGGGAGACGGCC TGTTTGGGGAAGTCTTACGCCCAAATGTGGAGCTTGATGTACTTCCACAGACGTGATCTC AGGCTAGCGGCAAATGCCATCTGCTCGGCAGTCCCGTCACACTGGGTTCCAACAAGCCGG ACAACCTGGTCCATACACGCCAGCCATGAATGGATGACGACGGAAGACATGTTGACAGTT TGGAACAAAGTGTGGATCCTAGAAAATCCATGGATGGAAGACAAAACTCCAGTGGAATCA TGGGAGGAAATCCCATACCTGGGAAAAAGAGAAGACCAATGGTGCGGCTCACTGATTGGG CTGACAAGCAGAGCCACCTGGGCGAAGAATATCCAGACAGCAATAAACCAAGTCAGATCC CTCATTGGCAATGAGGAATACACAGATTACATGCCATCCATGAAAAGATTCAGAAGAGAA GAGGAAGAGGCAGGAGTTTTGTGGTAG PF01003 Flavi_capsid PF07652 Flavi_DEAD PF02832 Flavi_glycop_C PF00869 Flavi_glycoprot PF01004 Flavi_M PF00948 Flavi_NS1 PF01005 Flavi_NS2A PF01002 Flavi_NS2B PF01350 Flavi_NS4A PF01349 Flavi_NS4B PF00972 Flavi_NS5 PF01570 Flavi_propep PF01728 FtsJ PF00949 Peptidase_S7 component virion component viral envelope component viral capsid component cell component intrinsic to membrane component integral to membrane component membrane function catalytic activity function transferase activity, transferring phosphorus-containing groups function hydrolase activity function nucleic acid binding function nucleotide binding function RNA binding function purine nucleotide binding function structural molecule activity function helicase activity function adenyl nucleotide binding function peptidase activity function ATP-dependent helicase activity function transferase activity function endopeptidase activity function serine-type endopeptidase activity function RNA helicase activity function nucleotidyltransferase activity function double-stranded RNA binding function RNA-directed RNA polymerase activity function binding function ATP binding process viral infectious cycle process viral genome replication process viral life cycle BE0000722 Inosine-5'-monophosphate dehydrogenase 2 Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Inosine-5'-monophosphate dehydrogenase 2 Nucleotide transport and metabolism Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors IMPDH2 3p21.2 None 6.9 55806.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:6053 GenAtlas IMPDH2 GeneCards IMPDH2 GenBank Gene Database J04208 GenBank Protein Database 307066 UniProtKB P12268 UniProt Accession IMDH2_HUMAN EC 1.1.1.205 IMP dehydrogenase 2 IMPD 2 IMPDH-II >Inosine-5'-monophosphate dehydrogenase 2 MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF >1545 bp ATGGCCGACTACCTGATTAGTGGGGGCACGTCCTACGTGCCAGACGACGGACTCACAGCA CAGCAGCTCTTCAACTGCGGAGACGGCCTCACCTACAATGACTTTCTCATTCTCCCTGGG TACATCGACTTCACTGCAGACCAGGTGGACCTGACTTCTGCTCTGACCAAGAAAATCACT CTTAAGACCCCACTGGTTTCCTCTCCCATGGACACAGTCACAGAGGCTGGGATGGCCATA GCAATGGCGCTTACAGGCGGTATTGGCTTCATCCACCACAACTGTACACCTGAATTCCAG GCCAATGAAGTTCGGAAAGTGAAGAAATATGAACAGGGATTCATCACAGACCCTGTGGTC CTCAGCCCCAAGGATCGCGTGCGGGATGTTTTTGAGGCCAAGGCCCGGCATGGTTTCTGC GGTATCCCAATCACAGACACAGGCCGGATGGGGAGCCGCTTGGTGGGCATCATCTCCTCC AGGGACATTGATTTTCTCAAAGAGGAGGAACATGACTGTTTCTTGGAAGAGATAATGACA AAGAGGGAAGACTTGGTGGTAGCCCCCCGCAGCATCACACTGAAGGAGGCAAATGAAATT CTGCAGCGCAGCAAGAAGGGAAAGTTGCCCATTGTAAATGAAGATGATGAGCTTGTGGCC ATCATTGCCCGGACAGACCTGAAGAAGAATCGGGACTACCCACTAGCCTCCAAAGATGCC AAGAAACAGCTGCTGTGTGGGGCAGCCATTGGCACTCATGAGGATGACAAGTATAGGCTG GACTTGCTCGCCCAGGCTGGTGTGGATGTAGTGGTTTTGGACTCTTCCCAGGGAAATTCC ATCTTCCAGATCAATATGATCAAGTACATCAAAGACAAATACCCTAATCTCCAAGTCATT GGAGGCAATGTGGTCACTGCTGCCCAGGCCAAGAACCTCATTGATGCAGGTGTGGATGCC CTGCGGGTGGGCATGGGAAGTGGCTCCATCTGCATTACGCAGGAAGTGCTGGCCTGTGGG CGGCCCCAAGCAACAGCAGTGTACAAGGTGTCAGAGTATGCACGGCGCTTTGGTGTTCCG GTCATTGCTGATGGAGGAATCCAAAATGTGGGTCATATTGCGAAAGCCTTGGCCCTTGGG GCCTCCACAGTCATGATGGGCTCTCTCCTGGCTGCCACCACTGAGGCCCCTGGTGAATAC TTCTTTTCCGATGGGATCCGGCTAAAGAAATATCGCGGTATGGGTTCTCTCGATGCCATG GACAAGCACCTCAGCAGCCAGAACAGATATTTCAGTGAAGCTGACAAAATCAAAGTGGCC CAGGGAGTGTCTGGTGCTGTGCAGGACAAAGGGTCAATCCACAAATTTGTCCCTTACCTG ATTGCTGGCATCCAACACTCATGCCAGGACATTGGTGCCAAGAGCTTGACCCAAGTCCGA GCCATGATGTACTCTGGGGAGCTTAAGTTTGAGAAGAGAACGTCCTCAGCCCAGGTGGAA GGTGGCGTCCATAGCCTCCATTCGTATGAGAAGCGGCTTTTCTGA PF00571 CBS PF00478 IMPDH function catalytic activity function IMP dehydrogenase activity function oxidoreductase activity function oxidoreductase activity, acting on CH-OH group of donors function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor process purine ribonucleoside monophosphate biosynthesis process physiological process process GMP biosynthesis process purine nucleotide metabolism process metabolism process purine nucleotide biosynthesis process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process nucleotide metabolism process purine nucleoside monophosphate biosynthesis "

owl:sameAs

drug:Abacavir

drug:EXPT02825

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