Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB02940"
| Predicate | Value (sorted: none) |
|---|---|
| drugbank:description |
"
experimental
This compound belongs to the thiazolines. These are heterocyclic compounds containing a five-member unsaturated aliphatic ring with one nitrogen atom, one sulfur atom, three carbon atoms.
Thiazolines
Organic Compounds
Heterocyclic Compounds
Azolines
Thiazolines
Imidothioesters
Enolates
Polyamines
Enamines
Carboxylic Acids
imidothioester
carboxylic acid
enolate
enamine
carboxylic acid derivative
polyamine
amine
organonitrogen compound
logP
0.36
ALOGPS
logS
-2
ALOGPS
Water Solubility
1.65e+00 g/l
ALOGPS
logP
-0.23
ChemAxon
IUPAC Name
(4S)-2-[(1Z)-1-aminoprop-1-en-1-yl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid
ChemAxon
Traditional IUPAC Name
(4S)-2-[(1Z)-1-aminoprop-1-en-1-yl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid
ChemAxon
Molecular Weight
186.231
ChemAxon
Monoisotopic Weight
186.046298264
ChemAxon
SMILES
[H][C@@]1(CSC(=N1)C(\N)=C\C)C(O)=O
ChemAxon
Molecular Formula
C7H10N2O2S
ChemAxon
InChI
InChI=1S/C7H10N2O2S/c1-2-4(8)6-9-5(3-12-6)7(10)11/h2,5H,3,8H2,1H3,(H,10,11)/b4-2-/t5-/m1/s1
ChemAxon
InChIKey
InChIKey=FDEYZMSECWCRCN-DWFCDSDJSA-N
ChemAxon
Polar Surface Area (PSA)
75.68
ChemAxon
Refractivity
48.67
ChemAxon
Polarizability
18.4
ChemAxon
Rotatable Bond Count
2
ChemAxon
H Bond Acceptor Count
4
ChemAxon
H Bond Donor Count
2
ChemAxon
pKa (strongest acidic)
3.6
ChemAxon
pKa (strongest basic)
4.23
ChemAxon
Physiological Charge
-1
ChemAxon
Number of Rings
1
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
Ghose Filter
true
ChemAxon
PubChem Compound
5289509
PubChem Substance
46504725
ChemSpider
4451461
PDB
TZB
BE0004325
Thiostrepton
Streptomyces azureus
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Thiostrepton
Involved in defense response to bacterium
Has bacteriocidal activity. Inhibits bacterial protein biosynthesis by acting on the elongation factor Tu (EF-Tu) (By similarity)
Secreted (By similarity)
None
5.63
1640.8
Streptomyces azureus
UniProtKB
P0C8P8
UniProt Accession
THCL_STRAJ
Alaninamide
Bryamycin
Gargon
Thiactin
>Thiostrepton
IASASCTTCICTCSCSS
BE0004326
50S ribosomal protein L11
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
50S ribosomal protein L11
Involved in rRNA binding
This protein binds directly to 23S ribosomal RNA
rplK
None
10.39
15088.8
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
GeneCards
rplK
GenBank Gene Database
Z11839
GenBank Protein Database
407022
UniProtKB
P29395
UniProt Accession
RL11_THEMA
>50S ribosomal protein L11
MAKKVAAQIKLQLPAGKATPAPPVGPALGQHGVNIMEFCKRFNAETADKAGMILPVVITV
YEDKSFTFIIKTPPASFLLKKAAGIEKGSSEPKRKIVGKVTRKQIEEIAKTKMPDLNANS
LEAAMKIIEGTAKSMGIEVVD
>150 bp
ATGCGAGTGAAAGTGGCTCTGAAATGTTCTCAGTGCGGTAACAAGAACTACTACACCACA
AGGAACAAGGACAAAAGAGCAAAGCTCGAACTGAGAAAGTACTGCCCAAAGTGCAACGCC
CACACGATTCATACCGAAACGAAAGCGTAA
PF00298
Ribosomal_L11
PF03946
Ribosomal_L11_N
component
protein complex
component
ribonucleoprotein complex
component
ribosome
component
cell
component
intracellular
function
structural molecule activity
function
structural constituent of ribosome
process
macromolecule biosynthesis
process
protein biosynthesis
process
physiological process
process
metabolism
process
macromolecule metabolism
"
|
| owl:sameAs | |
| rdfs:label |
"(4s)-2-[(1e)-1-Aminoprop-1-Enyl]-4,5-Dihydro-1,3-Thiazole-4-Carboxylic Acid"
|
| rdf:type |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt
The resource does not appear as an object