Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB03817"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"2,4-Diaminobutyric Acid"
|
| rdf:type | |
| drugbank:description |
"
1758-80-1
experimental
This compound belongs to the alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
Alpha Amino Acids and Derivatives
Organic Compounds
Organic Acids and Derivatives
Carboxylic Acids and Derivatives
Amino Acids, Peptides, and Analogues
Amino Fatty Acids
Enolates
Polyamines
Carboxylic Acids
Monoalkylamines
carboxylic acid
enolate
polyamine
primary amine
amine
primary aliphatic amine
organonitrogen compound
alpha,gamma-Diaminobutyrate
L-2,4-Diaminobutanoate
L-2,4-Diaminobutyrate
logP
-3.7
ALOGPS
logS
0.36
ALOGPS
Water Solubility
2.70e+02 g/l
ALOGPS
logP
-4
ChemAxon
IUPAC Name
(2S)-2,4-diaminobutanoic acid
ChemAxon
Traditional IUPAC Name
2,4-diaminobutyric acid
ChemAxon
Molecular Weight
118.1344
ChemAxon
Monoisotopic Weight
118.074227574
ChemAxon
SMILES
NCC[C@H](N)C(O)=O
ChemAxon
Molecular Formula
C4H10N2O2
ChemAxon
InChI
InChI=1S/C4H10N2O2/c5-2-1-3(6)4(7)8/h3H,1-2,5-6H2,(H,7,8)/t3-/m0/s1
ChemAxon
InChIKey
InChIKey=OGNSCSPNOLGXSM-VKHMYHEASA-N
ChemAxon
Polar Surface Area (PSA)
89.34
ChemAxon
Refractivity
28.56
ChemAxon
Polarizability
11.89
ChemAxon
Rotatable Bond Count
3
ChemAxon
H Bond Acceptor Count
4
ChemAxon
H Bond Donor Count
3
ChemAxon
pKa (strongest acidic)
2.55
ChemAxon
pKa (strongest basic)
10.25
ChemAxon
Physiological Charge
1
ChemAxon
Number of Rings
0
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
ChEBI
16028
PubChem Compound
134490
PubChem Substance
46508539
KEGG Compound
C03283
PDB
DAB
BE0002838
Envelope glycoprotein gp160
HIV-1
unknown
Envelope glycoprotein gp160
Involved in structural molecule activity
Allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves
env
TM:Virion
681-701
9.21
97204.0
HIV-1
GenBank Gene Database
M21098
UniProtKB
P12488
UniProt Accession
ENV_HV1BN
Env polyprotein
Envelope glycoprotein gp160 precursor
>Envelope glycoprotein gp160
MRVKGIKKNYQHLWRWGGMMLLGILMICSATDKLWVTVYYGVPVWKEANTTLFCASDAKA
YDTEIHNVWATHACVPTDPNPQELVMGNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCV
KLTPLCVTLNCHDFNATNATSNSGKMMEGGEMKNCSFNITTSIRDKMQKEYALFYKLDIV
PIDNDKTNTRYRLISCNTSVITQACPKVTFEPIPIHYCAPAGFAILKCNNKKFNGTGPCT
NVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSENFTNNVKTIIVQLNESVEINCTRPN
NNTRKRITMGPGRVYYTTGQIIGDIRRAHCNLSRSKWENTLKQIVTKLRVQFKNKTIVFN
RSSGGDPEIVMHSFNCGGEFFFCNTTQLFNSTWYRNTTGNITEGNSPITLPCRIKQIINM
WQEVGKAMYAPPIRGQIKCSSNITGLLLTRDGGNNNETTDTEIFRPGGGNMRDNWRSELY
KYKVVKIEPLGVAPTKAKRRVVQREKRAVGLGALFLGFLGAAGSTMGAASLTLTVQARLL
LSGIVQQQNNLLMAIEAQQHMLELTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGKLIC
TTAVPWNASWSNKSLSDIWDNMTWMEWEREIDNYTNLIYSLIEDSQIQQEKNEKELLELD
KWASLWNWFNITNWLWYIKIFIMIVGGLIGLRIVFAVLSIVNRVRQGYSPLSFQTRLPGR
RGPDRPEGIEEEGGERDRDRSSPLVDGFLALFWVDLRSLFLFSYHRLRDLLLIVTRIVEL
LGRRGWEVLKYWWNLLQYWSQELKNSAVSLLNATAIAVGERTDRAIEVVQRAFRAILHIP
RRIRQGLERALQ
>2559 bp
ATGAGAGTGAAGGGGATCAAGAAGAATTATCAGCACTTGTGGAGATGGGGGGGCATGATG
CTCCTTGGGATATTGATGATCTGTAGTGCTACAGACAAATTGTGGGTCACAGTCTATTAT
GGGGTACCTGTGTGGAAAGAAGCAAACACCACTCTATTTTGTGCATCAGATGCTAAAGCA
TATGATACAGAGATACATAATGTCTGGGCCACACATGCCTGTGTACCCACAGACCCCAAC
CCACAAGAATTAGTAATGGGAAATGTGACAGAAAATTTTAACATGTGGAAAAATGACATG
GTAGAACAGATGCATGAGGATATAATCAGTTTATGGGATCAAAGCCTAAAGCCATGTGTA
AAATTAACCCCACTCTGTGTTACTTTAAATTGCCATGATTTCAATGCTACTAATGCCACT
AGTAATAGCGGGAAAATGATGGAGGGAGGAGAAATGAAAAACTGCTCTTTCAATATCACC
ACAAGCATAAGAGATAAGATGCAGAAAGAATATGCACTTTTTTATAAACTTGATATAGTA
CCAATAGATAATGATAAAACTAATACTAGATATAGGTTGATAAGTTGTAATACCTCAGTC
ATTACACAGGCCTGTCCAAAGGTAACCTTTGAGCCAATTCCCATACATTATTGTGCCCCG
GCTGGTTTTGCGATTCTAAAGTGTAATAATAAGAAGTTCAATGGAACAGGACCATGTACA
AATGTCAGCACAGTACAATGTACACATGGAATTAGGCCAGTAGTATCCACTCAATTGCTG
TTAAATGGCAGTCTAGCAGAAGAAGAGGTAGTAATTAGATCTGAAAATTTCACGAACAAT
GTTAAAACCATAATAGTACAGCTGAATGAATCTGTAGAAATTAATTGTACAAGACCCAAC
AACAATACAAGAAAGAGGATAACTATGGGACCAGGGAGAGTATATTATACAACAGGACAA
ATAATAGGAGATATAAGACGAGCACATTGTAACCTTAGTAGATCAAAATGGGAGAACACT
TTAAAACAGATAGTTACAAAATTAAGAGTACAATTTAAGAATAAAACAATAGTCTTTAAT
CGATCCTCAGGAGGGGACCCAGAAATTGTAATGCACAGTTTTAATTGTGGAGGGGAATTT
TTCTTCTGTAATACAACACAACTGTTTAATAGTACTTGGTATAGGAACACTACAGGAAAT
ATCACTGAAGGAAATAGCCCAATCACACTCCCATGCAGAATAAAACAAATTATAAACATG
TGGCAGGAAGTAGGAAAAGCAATGTATGCCCCTCCCATCAGAGGACAAATTAAATGTTCA
TCAAATATTACAGGGCTGCTATTAACAAGAGATGGTGGTAATAACAACGAGACCACCGAC
ACCGAGATCTTCAGACCTGGAGGAGGAAATATGAGGGACAATTGGAGAAGTGAATTATAT
AAATATAAAGTAGTAAAAATTGAACCATTAGGAGTAGCACCCACCAAGGCAAAGAGAAGA
GTGGTGCAGAGAGAAAAAAGAGCAGTGGGACTAGGAGCTTTGTTCCTTGGGTTCTTAGGA
GCAGCAGGAAGCACTATGGGCGCAGCGTCCCTGACGCTGACGGTACAGGCCAGACTATTA
TTGTCTGGTATAGTGCAACAGCAGAACAACTTGCTGATGGCTATTGAGGCGCAACAGCAT
ATGTTGGAACTTACAGTCTGGGGCATCAAGCAGCTCCAGGCAAGAGTCCTGGCTGTAGAA
AGATACCTAAAGGACCAACAGCTCCTGGGGATTTGGGGTTGCTCTGGAAAACTCATTTGC
ACCACTGCTGTGCCTTGGAATGCTAGTTGGAGTAATAAATCTCTGAGTGACATTTGGGAT
AACATGACCTGGATGGAGTGGGAAAGAGAAATTGACAATTATACAAACTTAATATACTCC
TTAATTGAGGACTCGCAAATCCAACAAGAAAAGAATGAAAAAGAATTATTAGAATTAGAC
AAGTGGGCAAGTTTGTGGAATTGGTTCAACATAACAAACTGGCTGTGGTATATAAAAATA
TTCATAATGATAGTAGGGGGCTTGATAGGTTTAAGAATAGTTTTTGCTGTACTTTCTATA
GTGAATAGAGTTAGGCAGGGATACTCACCATTATCGTTTCAGACCCGCCTCCCAGGCCGG
AGGGGACCCGACAGGCCCGAAGGAATCGAAGAAGAAGGTGGAGAGCGAGACAGAGACAGA
TCCAGTCCCTTAGTGGATGGATTCTTAGCACTTTTCTGGGTCGATCTGCGGAGCCTGTTC
CTCTTCAGCTACCACCGCTTGAGAGACTTACTCTTGATTGTAACGAGGATTGTGGAACTT
CTGGGACGCAGGGGGTGGGAAGTCCTCAAATATTGGTGGAATCTCCTACAGTATTGGAGT
CAGGAACTAAAGAATAGTGCTGTTAGCTTGCTCAACGCCACAGCCATAGCAGTAGGTGAG
AGGACAGATAGGGCTATAGAAGTAGTACAAAGAGCTTTTAGAGCTATCCTGCACATACCT
AGAAGAATAAGACAGGGCTTGGAAAGGGCTTTGCAATAA
PF00517
GP41
PF00516
GP120
component
virion
component
viral envelope
function
structural molecule activity
"
|
| owl:sameAs |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt
The resource does not appear as an object