Resource Glyoxalate, Glyoxylate

Predicate	Value (sorted: none)
rdf:type	drugbank:drugs
owl:sameAs	drug:Orotidine-5'-Monophosphate
owl:sameAs	drug:L-Isoleucine
owl:sameAs	drug:Pyruvic acid
owl:sameAs	drug:Creatine
owl:sameAs	drug:L-Cysteine
owl:sameAs	drug:S-Adenosylmethionine
owl:sameAs	drug:3-Hydroxypyruvic Acid
drugbank:description	" 298-12-4 experimental This compound belongs to the polyamines. These are compounds containing more than one amine group. Polyamines Organic Compounds Organonitrogen Compounds Amines Polyamines Enolates Carboxylic Acids Aldehydes aldehyde logP -0.59 ALOGPS logS 0.48 ALOGPS Water Solubility 2.24e+02 g/l ALOGPS logP -0.13 ChemAxon IUPAC Name 2-oxoacetic acid ChemAxon Traditional IUPAC Name glyoxalate, glyoxylate ChemAxon Molecular Weight 74.0355 ChemAxon Monoisotopic Weight 74.00039393 ChemAxon SMILES OC(=O)C=O ChemAxon Molecular Formula C2H2O3 ChemAxon InChI InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5) ChemAxon InChIKey InChIKey=HHLFWLYXYJOTON-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 54.37 ChemAxon Refractivity 13.5 ChemAxon Polarizability 5.35 ChemAxon Rotatable Bond Count 1 ChemAxon H Bond Acceptor Count 3 ChemAxon H Bond Donor Count 1 ChemAxon pKa (strongest acidic) 2.61 ChemAxon pKa (strongest basic) -9.2 ChemAxon Physiological Charge -1 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Melting Point 98 Â°C PhysProp pKa 3.3 (at 25 Â°C) DEAN,JA (1985) ChEBI 16891 PubChem Compound 760 PubChem Substance 46507705 KEGG Compound C00048 BindingDB 19472 PDB GLV SMP00721 3-Phosphoglycerate dehydrogenase deficiency DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00313 Lactic Acidemia DB00119 Pyruvic acid DB00121 Biotin DB00142 L-Glutamic Acid DB00145 Glycine DB00160 L-Alanine DB00167 L-Isoleucine DB01593 Zinc DB04343 Glyoxalate, Glyoxylate P49588 P24298 P11498 P21549 Q5JTZ9 SMP00055 Alanine Metabolism DB00119 Pyruvic acid DB00121 Biotin DB00142 L-Glutamic Acid DB00145 Glycine DB00160 L-Alanine DB00167 L-Isoleucine DB01593 Zinc DB04343 Glyoxalate, Glyoxylate P49588 P24298 P11498 P21549 Q5JTZ9 SMP00004 Glycine and Serine Metabolism DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00350 Pyruvate Carboxylase Deficiency DB00119 Pyruvic acid DB00121 Biotin DB00142 L-Glutamic Acid DB00145 Glycine DB00160 L-Alanine DB00167 L-Isoleucine DB01593 Zinc DB04343 Glyoxalate, Glyoxylate P49588 P24298 P11498 P21549 Q5JTZ9 SMP00179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00242 Dimethylglycine Dehydrogenase Deficiency DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00484 Dimethylglycinuria DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00223 Non Ketotic Hyperglycinemia DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00485 Hyperglycinemia, non-ketotic DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00352 Primary Hyperoxaluria Type I DB00119 Pyruvic acid DB00121 Biotin DB00142 L-Glutamic Acid DB00145 Glycine DB00160 L-Alanine DB00167 L-Isoleucine DB01593 Zinc DB04343 Glyoxalate, Glyoxylate P49588 P24298 P11498 P21549 Q5JTZ9 SMP00244 Sarcosinemia DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 BE0001216 Malate synthase G Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Malate synthase G Energy production and conversion Accounts for almost the entire malate-synthesizing activity in cells metabolizing glyoxylate glcB Cytoplasm None 6.09 80490.0 Escherichia coli (strain K12) GenBank Gene Database X74547 GenBank Protein Database 517247 UniProtKB P37330 UniProt Accession MASZ_ECOLI EC 2.3.3.9 MSG >Malate synthase G MSQTITQSRLRIDANFKRFVDEEVLPGTGLDAAAFWRNFDEIVHDLAPENRQLLAERDRI QAALDEWHRSNPGPVKDKAAYKSFLRELGYLVPQPERVTVETTGIDSEITSQAGPQLVVP AMNARYALNAANARWGSLYDALYGSDIIPQEGAMVSGYDPQRGEQVIAWVRRFLDESLPL ENGSYQDVVAFKVVDKQLRIQLKNGKETTLRTPAQFVGYRGDAAAPTCILLKNNGLHIEL QIDANGRIGKDDPAHINDVIVEAAISTILDCEDSVAAVDAEDKILLYRNLLGLMQGTLQE KMEKNGRQIVRKLNDDRHYTAADGSEISLHGRSLLFIRNVGHLMTIPVIWDSEGNEIPEG ILDGVMTGAIALYDLKVQKNSRTGSVYIVKPKMHGPQEVAFANKLFTRIETMLGMAPNTL KMGIMDEERRTSLNLRSCIAQARNRVAFINTGFLDRTGDEMHSVMEAGPMLRKNQMKSTP WIKAYERNNVLSGLFCGLRGKAQIGKGMWAMPDLMADMYSQKGDQLRAGANTAWVPSPTA ATLHALHYHQTNVQSVQANIAQTEFNAEFEPLLDDLLTIPVAENANWSAQEIQQELDNNV QGILGYVVRWVEQGIGCSKVPDIHNVALMEDRATLRISSQHIANWLRHGILTKEQVQASL ENMAKVVDQQNAGDPAYRPMAGNFANSCAFKAASDLIFLGVKQPNGYTEPLLHAWRLREK ESH >2172 bp ATGAGTCAAACCATAACCCAGAGCCGTTTACGCATTGACGCCAATTTTAAACGTTTTGTG GATGAAGAAGTTTTACCGGGAACAGGGCTGGACGCTGCGGCGTTCTGGCGCAATTTTGAT GAGATCGTTCATGATCTGGCACCAGAAAATCGTCAGTTGCTGGCAGAACGCGATCGCATT CAGGCAGCGCTTGATGAGTGGCATCGCAGCAATCCGGGGCCGGTAAAAGATAAAGCGGCC TATAAATCTTTCCTGCGTGAACTGGGCTACCTGGTGCCGCAACCGGAGCGCGTGACGGTG GAAACCACGGGCATTGACAGCGAAATCACCAGCCAGGCGGGGCCGCAGCTGGTGGTTCCG GCAATGAACGCCCGCTACGCGCTGAACGCGGCGAACGCTCGCTGGGGCTCACTGTACGAT GCGTTATACGGCAGCGACATCATCCCGCAGGAAGGGGCGATGGTCAGCGGCTACGATCCG CAACGCGGTGAGCAGGTTATCGCCTGGGTTCGGCGTTTCCTCGATGAATCTCTACCGCTG GAAAACGGCAGCTATCAGGATGTGGTGGCGTTTAAGGTGGTTGATAAACAATTACGCATC CAGTTGAAAAATGGTAAAGAAACCACGTTACGTACTCCAGCACAGTTTGTCGGTTACCGT GGCGATGCCGCTGCGCCGACCTGCATTTTGCTGAAAAATAACGGCCTGCATATTGAGCTG CAAATCGATGCCAATGGGCGGATTGGCAAAGACGATCCGGCGCACATCAACGATGTTATC GTCGAAGCTGCTATCAGTACCATTCTCGACTGCGAAGATTCGGTCGCGGCGGTTGATGCG GAAGATAAAATCCTGCTGTACCGCAACCTGCTGGGCCTGATGCAGGGGACTCTGCAAGAG AAAATGGAGAAAAACGGTCGGCAAATCGTGCGTAAACTGAATGACGATCGTCATTACACC GCCGCCGATGGCTCTGAAATTTCTCTGCACGGACGCTCGCTGCTGTTTATCCGCAACGTG GGTCATTTGATGACCATTCCTGTGATTTGGGACAGCGAAGGCAATGAAATCCCGGAAGGC ATTCTTGATGGCGTCATGACTGGCGCGATTGCCCTCTATGATTTAAAAGTGCAGAAAAAC TCGCGCACTGGCAGCGTCTATATTGTGAAACCGAAAATGCACGGTCCGCAGGAAGTGGCG TTCGCCAACAAACTGTTTACCCGCATTGAGACAATGCTCGGTATGGCACCGAATACCCTG AAAATGGGCATTATGGATGAAGAACGTCGGACCTCGCTGAACTTGCGTAGCTGTATCGCT CAGGCGCGCAACCGCGTGGCGTTCATCAATACCGGTTTCCTCGACCGTACCGGCGATGAA ATGCATTCGGTGATGGAAGCTGGCCCGATGCTGCGTAAAAATCAGATGAAATCGACGCCT TGGATCAAAGCCTACGAGCGTAATAACGTGCTTTCCGGTCTGTTCTGTGGGCTGCGCGGT AAAGCGCAAATTGGTAAAGGCATGTGGGCAATGCCGGACCTGATGGCAGACATGTACAGC CAGAAGGGCGACCAACTGCGTGCCGGGGCAAACACAGCCTGGGTTCCGTCACCAACCGCT GCTACGCTCCATGCGCTGCACTACCACCAAACCAACGTACAGAGCGTACAAGCCAACATT GCCCAGACCGAGTTCAATGCTGAATTTGAACCGCTGCTGGACGATCTGCTGACTATTCCG GTTGCTGAAAACGCTAACTGGTCGGCGCAAGAGATCCAACAAGAGCTGGATAACAACGTG CAGGGGATTCTGGGGTACGTGGTGCGCTGGGTGGAGCAGGGGATTGGTTGTTCAAAAGTG CCGGATATTCACAATGTGGCGTTGATGGAAGACCGCGCAACGCTGCGTATCTCCAGCCAG CATATCGCCAACTGGTTACGTCACGGTATTCTGACCAAAGAACAGGTGCAGGCGTCGCTG GAGAATATGGCGAAAGTGGTTGATCAGCAAAACGCTGGCGATCCGGCTTATCGTCCGATG GCGGGGAATTTCGCTAACTCGTGTGCTTTTAAAGCTGCCAGCGATTTAATCTTCCTCGGC GTGAAACAGCCAAACGGCTATACCGAACCGTTATTACACGCCTGGCGTTTACGCGAAAAA GAAAGTCATTAA PF01274 Malate_synthase function transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer function malate synthase activity function catalytic activity function transferase activity function transferase activity, transferring acyl groups process physiological process process glyoxylate cycle process metabolism process cellular metabolism process generation of precursor metabolites and energy process energy derivation by oxidation of organic compounds process main pathways of carbohydrate metabolism process tricarboxylic acid cycle BE0001761 Isocitrate lyase Mycobacterium tuberculosis # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Isocitrate lyase Energy production and conversion Isocitrate = succinate + glyoxylate icl Cytoplasm None 4.79 47087.0 Mycobacterium tuberculosis GenBank Gene Database BX842573 GenBank Protein Database 38490185 UniProtKB P0A5H3 UniProt Accession ACEA_MYCTU EC 4.1.3.1 ICL Isocitrase Isocitratase >Isocitrate lyase MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQL HDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQV VRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSH WEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSD VDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEA VKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFD LAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTG STEEGQFH >1287 bp ATGTCTGTCGTCGGCACCCCGAAGAGCGCGGAGCAGATCCAGCAGGAATGGGACACGAAC CCGCGCTGGAAGGACGTCACCCGCACCTACTCCGCCGAGGACGTCGTCGCCCTCCAGGGC AGCGTGGTCGAGGAGCACACGCTGGCCCGCCGCGGTGCGGAGGTGCTGTGGGAGCAGCTG CACGACCTCGAGTGGGTCAACGCGCTGGGCGCGCTGACCGGCAACATGGCCGTCCAGCAG GTGCGCGCCGGCCTGAAGGCCATCTACCTGTCGGGCTGGCAGGTCGCCGGCGATGCCAAC CTGTCCGGGCACACCTACCCCGACCAGAGCCTGTATCCCGCCAACTCGGTGCCGCAGGTG GTCCGCCGGATCAACAACGCACTGCAGCGCGCCGACCAGATCGCCAAGATCGAGGGCGAT ACTTCGGTGGAGAACTGGCTGGCGCCGATTGTCGCCGACGGCGAGGCCGGCTTTGGCGGC GCGCTCAACGTCTACGAGCTGCAGAAAGCCCTGATCGCCGCGGGCGTTGCGGGTTCGCAC TGGGAGGACCAGTTGGCCTCTGAGAAGAAGTGCGGCCACCTGGGCGGCAAGGTGTTGATC CCGACCCAGCAGCACATCCGCACTTTGACGTCTGCTCGGCTCGCGGCCGATGTGGCTGAT GTTCCCACGGTGGTGATCGCCCGTACCGACGCCGAGGCGGCCACGCTGATCACCTCCGAC GTCGACGAGCGCGACCAGCCGTTCATCACCGGCGAGCGCACCCGGGAAGGCTTCTACCGC ACCAAGAACGGCATCGAGCCTTGCATCGCTCGGGCGAAGGCCTACGCCCCGTTCGCCGAC TTGATCTGGATGGAGACCGGTACCCCGGACCTCGAGGCCGCCCGGCAGTTCTCCGAGGCG GTCAAGGCGGAGTACCCGGACCAGATGCTGGCCTACAACTGCTCGCCATCGTTCAACTGG AAAAAGCACCTCGACGACGCCACCATCGCCAAGTTCCAGAAGGAGCTGGCAGCCATGGGC TTCAAGTTCCAGTTCATCACGCTGGCCGGCTTCCATGCGCTGAACTACTCGATGTTCGAT CTGGCCTACGGCTACGCCCAGAACCAGATGAGCGCGTATGTCGAACTGCAGGAACGCGAG TTCGCCGCCGAAGAACGGGGCTACACCGCGACCAAGCACCAGCGCGAGGTCGGCGCCGGC TACTTCGACCGGATTGCCACCACCGTGGACCCGAATTCGTCGACCACCGCGTTGACCGGT TCCACCGAAGAGGGCCAGTTCCACTAG PF00463 ICL function carbon-carbon lyase activity function oxo-acid-lyase activity function isocitrate lyase activity function catalytic activity function lyase activity process generation of precursor metabolites and energy process energy derivation by oxidation of organic compounds process main pathways of carbohydrate metabolism process glyoxylate cycle process physiological process process metabolism process cellular metabolism BE0001750 Malate synthase G Mycobacterium tuberculosis # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Malate synthase G Energy production and conversion Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA glcB Cytoplasm None 4.83 80404.0 Mycobacterium tuberculosis GenBank Gene Database BX842578 GenBank Protein Database 1483534 UniProtKB P0A5J4 UniProt Accession MASZ_MYCTU EC 2.3.3.9 >Malate synthase G MTDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVADLTPQNQALLNARDEL QAQIDKWHRRRVIEPIDMDAYRQFLTEIGYLLPEPDDFTITTSGVDAEITTTAGPQLVVP VLNARFALNAANARWGSLYDALYGTDVIPETDGAEKGPTYNKVRGDKVIAYARKFLDDSV PLSSGSFGDATGFTVQDGQLVVALPDKSTGLANPGQFAGYTGAAESPTSVLLINHGLHIE ILIDPESQVGTTDRAGVKDVILESAITTIMDFEDSVAAVDAADKVLGYRNWLGLNKGDLA AAVDKDGTAFLRVLNRDRNYTAPGGGQFTLPGRSLMFVRNVGHLMTNDAIVDTDGSEVFE GIMDALFTGLIAIHGLKASDVNGPLINSRTGSIYIVKPKMHGPAEVAFTCELFSRVEDVL GLPQNTMKIGIMDEERRTTVNLKACIKAAADRVVFINTGFLDRTGDEIHTSMEAGPMVRK GTMKSQPWILAYEDHNVDAGLAAGFSGRAQVGKGMWTMTELMADMVETKIAQPRAGASTA WVPSPTAATLHALHYHQVDVAAVQQGLAGKRRATIEQLLTIPLAKELAWAPDEIREEVDN NCQSILGYVVRWVDQGVGCSKVPDIHDVALMEDRATLRISSQLLANWLRHGVITSADVRA SLERMAPLVDRQNAGDVAYRPMAPNFDDSIAFLAAQELILSGAQQPNGYTEPILHRRRRE FKARAAEKPAPSDRAGDDAAR >2226 bp CTAGCGGGCCGCATCGTCACCGGCCCTGTCCGATGGGGCCGGCTTCTCAGCGGCCCGGGC CTTAAACTCCCGACGACGTCGGTGCAGGATCGGCTCGGTGTAGCCGTTGGGCTGCTGGGC CCCGGACAAGATCAGCTCCTGCGCGGCCAGGAAGGCGATACTGTCGTCGAAGTTGGGTGC CATCGGTCGGTATGCCACGTCGCCCGCGTTTTGTCGATCGACCAACGGCGCCATCCGCTC CAAGCTGGCCCGCACATCCGCGCTGGTGATCACACCGTGGCGCAGCCAGTTGGCCAACAA TTGGCTGGAGATTCGCAGCGTGGCCCGGTCCTCCATGAGCGCGACGTCGTGGATGTCGGG CACCTTCGAGCAGCCGACACCTTGATCAACCCAGCGAACCACGTAGCCGAGGATGGATTG ACAGTTGTTGTCGACCTCTTCGCGGATCTCGTCGGGAGCCCAGGCCAATTCCTTGGCCAG CGGAATGGTCAGCAATTGTTCGATGGTGGCGCGACGCTTCCCCGCCAGTCCTTGTTGCAC CGCGGCGACGTCGACCTGGTGGTAGTGCAGCGCATGCAGGGTGGCCGCAGTGGGAGAGGG AACCCAGGCGGTGCTGGCCCCGGCGCGCGGCTGGGCGATTTTTGTCTCGACCATGTCGGC CATCAGCTCGGTCATTGTCCACATGCCCTTGCCGACCTGGGCTCGGCCGCTGAACCCGGC GGCCAGGCCGGCATCGACGTTGTGGTCCTCGTAGGCCAAGATCCACGGCTGGCTCTTCAT GGTGCCCTTGCGCACCATCGGGCCGGCCTCCATCGAGGTGTGGATTTCATCGCCGGTGCG GTCCAGGAACCCGGTGTTGATGAACACCACGCGGTCCGCGGCAGCTTTGATGCACGCCTT GAGGTTGACCGTGGTCCGGCGTTCCTCGTCCATGATGCCGATCTTCATGGTGTTTTGCGG CAACCCCAGCACATCTTCAACCCGGCTGAACAGTTCGCAGGTAAACGCCACCTCGGCCGG ACCGTGCATCTTCGGCTTGACGATGTAGATGGAGCCGGTGCGGCTGTTGATCAGCGGCCC GTTGACGTCGCTGGCCTTTAGCCCGTGGATGGCGATCAGGCCGGTGAATAGGGCATCCAT GATGCCTTCGAACACCTCGCTGCCGTCAGTGTCGACGATGGCGTCATTCGTCATCAAGTG ACCGACGTTGCGGACGAACATGAGGCTGCGTCCAGGCAGCGTGAACTGGCCACCGCCGGG TGCGGTGTAGTTCCGGTCCCTATTGAGCACCCGCAGGAAAGCGGTGCCGTCCTTGTCTAC CGCTGCTGCCAGGTCGCCCTTGTTCAGGCCGAGCCAGTTCCGATAACCCAGCACCTTGTC GGCGGCGTCCACGGCGGCCACCGAGTCCTCGAAGTCCATGATCGTGGTGATCGCGGATTC CAGGATCACGTCCTTGACGCCGGCCCGGTCGGTGGTGCCGACCTGCGACTCCGGATCGAT CAGGATCTCGATGTGCAAACCGTGATTGATTAGCAGCACCGATGTCGGCGACTCGGCTGC GCCGGTGTAGCCGGCGAACTGGCCGGGGTTGGCCAGGCCGGTGGACTTATCCGGCAAGGC AACCACGAGCTGGCCATCCTGCACTGTGAAACCGGTGGCGTCGCCAAAGGAACCCGACGA CAGCGGAACACTGTCGTCGAGGAACTTGCGGGCATACGCGATCACCTTGTCGCCACGAAC CTTGTTGTACGTGGGGCCTTTTTCGGCGCCGTCGGTCTCGGGGATGACATCGGTGCCATA CAAGGCGTCGTAGAGGGAGCCCCAGCGAGCGTTGGCCGCGTTCAGAGCAAACCGCGCGTT GAGCACCGGCACCACCAGCTGGGGGCCGGCGGTCGTGGTGATCTCAGCGTCGACACCGGA CGTGGTGATGGTGAAGTCATCAGGTTCGGGAAGCAGGTAGCCGATCTCGGTGAGGAACTG GCGGTAGGCATCCATGTCGATGGGCTCGATCACCCGACGCCGGTGCCACTTGTCGATCTG CGCCTGCAGCTCGTCGCGGGCGTTCAACAGAGCTTGGTTCTGCGGGGTCAGGTCGGCGAC GACCTTGTCGACGCCCGCCCAGAAGCTGTCCGGGTCGATATCGGTGCCAGGCAGGGCTTC ATTGTTCACGAAGTCGTAGAGCACCCGAGCGATGCGCAAGTTGCCCACCGACACGCGATC TGTCAT PF01274 Malate_synthase function transferase activity function transferase activity, transferring acyl groups function transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer function malate synthase activity function catalytic activity process metabolism process cellular metabolism process generation of precursor metabolites and energy process energy derivation by oxidation of organic compounds process main pathways of carbohydrate metabolism process tricarboxylic acid cycle process physiological process process glyoxylate cycle BE0001689 Putative regulator of ribonuclease activity Mycobacterium tuberculosis # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Putative regulator of ribonuclease activity Coenzyme transport and metabolism Regulator of RNase E/rne, which inhibits the endonuclease activity and thereby leads to increase the half-life and abundance of RNAs. General modulator of RNA abundance. Does not have any methyltransferase activity Rv3853 None 4.84 16236.0 Mycobacterium tuberculosis GenBank Gene Database BX842584 GenBank Protein Database 1781103 UniProtKB P0A666 UniProt Accession RRAAH_MYCTU >Regulator of ribonuclease activity A MAISFRPTADLVDDIGPDVRSCDLQFRQFGGRSQFAGPISTVRCFQDNALLKSVLSQPSA GGVLVIDGAGSLHTALVGDVIAELARSTGWTGLIVHGAVRDAAALRGIDIGIKALGTNPR KSTKTGAGERDVEITLGGVTFVPGDIAYSDDDGIIVV >474 bp GTGGCCATCTCATTTCGCCCAACCGCTGACCTCGTCGACGACATCGGGCCCGACGTGCGC AGCTGTGACCTACAGTTCCGCCAATTCGGCGGCCGATCGCAGTTCGCCGGACCGATCAGC ACCGTGCGGTGTTTTCAGGACAATGCGTTGCTGAAGTCGGTGCTCTCGCAGCCAAGTGCG GGCGGTGTGCTGGTCATCGACGGCGCCGGGTCCCTGCACACCGCGTTGGTCGGTGATGTC ATCGCCGAGTTGGCCCGCTCTACCGGCTGGACCGGGTTGATCGTCCACGGCGCGGTGCGA GATGCCGCCGCGCTGCGCGGCATCGACATCGGCATCAAAGCGCTGGGCACCAATCCCCGC AAGAGCACCAAGACCGGTGCCGGAGAACGCGACGTTGAAATCACGCTGGGCGGGGTGACA TTCGTTCCGGGCGATATCGCCTACAGCGACGACGACGGCATCATCGTCGTCTGA PF03737 Methyltransf_6 BE0000449 Monocarboxylate transporter 4 Human substrate # Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11101640 unknown Monocarboxylate transporter 4 Carbohydrate transport and metabolism Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate SLC16A3 17q25 Cell membrane; multi-pass membrane protein 18-38 62-82 85-105 110-130 150-170 180-200 228-248 265-285 295-315 318-338 352-372 385-405 8.03 49470.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:10924 GenAtlas SLC16A3 GeneCards SLC16A3 GenBank Gene Database U81800 GenBank Protein Database 2463634 UniProtKB O15427 UniProt Accession MOT4_HUMAN MCT 3 MCT 4 Solute carrier family 16 member 3 >Monocarboxylate transporter 4 MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV >1398 bp ATGGGAGGGGCCGTGGTGGACGAGGGCCCCACAGGCGTCAAGGCCCCTGACGGCGGCTGG GGCTGGGCCGTGCTCTTCGGCTGTTTCGTCATCACTGGCTTCTCCTACGCCTTCCCCAAG GCCGTCAGTGTCTTCTTCAAGGAGCTCATACAGGAGTTTGGGATCGGCTACAGCGACACA GCCTGGATCTCCTCCATCCTGCTGGCCATGCTCTACGGGACAGGTCCGCTCTGCAGTGTG TGCGTGAACCGCTTTGGCTGCCGGCCCGTCATGCTTGTGGGGGGTCTCTTTGCGTCGCTG GGCATGGTGGCTGCGTCCTTTTGCCGGAGCATCATCCAGGTCTACCTCACCACTGGGGTC ATCACGGGGTTGGGTTTGGCACTCAACTTCCAGCCCTCGCTCATCATGCTGAACCGCTAC TTCAGCAAGCGGCGCCCCATGGCCAACGGGCTGGCGGCAGCAGGTAGCCCTGTCTTCCTG TGTGCCCTGAGCCCGCTGGGGCAGCTGCTGCAGGACCGCTACGGCTGGCGGGGCGGCTTC CTCATCCTGGGCGGCCTGCTGCTCAACTGCTGCGTGTGTGCCGCACTCATGAGGCCCCTG GTGGTCACGGCCCAGCCGGGCTCGGGGCCGCCGCGACCCTCCCGGCGCCTGCTAGACCTG AGCGTCTTCCGGGACCGCGGCTTTGTGCTTTACGCCGTGGCCGCCTCGGTCATGGTGCTG GGGCTCTTCGTCCCGCCCGTGTTCGTGGTGAGCTACGCCAAGGACCTGGGCGTGCCCGAC ACCAAGGCCGCCTTCCTGCTCACCATCCTGGGCTTCATTGACATCTTCGCGCGGCCGGCC GCGGGCTTCGTGGCGGGGCTTGGGAAGGTGCGGCCCTACTCCGTCTACCTCTTCAGCTTC TCCATGTTCTTCAACGGCCTCGCGGACCTGGCGGGCTCTACGGCGGGCGACTACGGCGGC CTCGTGGTCTTCTGCATCTTCTTTGGCATCTCCTACGGCATGGTGGGGGCCCTGCAGTTC GAGGTGCTCATGGCCATCGTGGGCACCCACAAGTTCTCCAGTGCCATTGGCCTGGTGCTG CTGATGGAGGCGGTGGCCGTGCTCGTCGGGCCCCCTTCGGGAGGCAAACTCCTGGATGCG ACCCACGTCTACATGTACGTGTTCATCCTGGCGGGGGCCGAGGTGCTCACCTCCTCCCTG ATTTTGCTGCTGGGCAACTTCTTCTGCATTAGGAAGAAGCCCAAAGAGCCACAGCCTGAG GTGGCGGCCGCGGAGGAGGAGAAGCTCCACAAGCCTCCTGCAGACTCGGGGGTGGACTTG CGGGAGGTGGAGCATTTCCTGAAGGCTGAGCCTGAGAAAAACGGGGAGGTGGTTCACACC CCGGAAACAAGTGTCTGA PF07690 MFS_1 component cell component intrinsic to membrane component integral to membrane component membrane function monocarboxylic acid transporter activity function transporter activity function monocarboxylate porter activity function organic acid transporter activity function carboxylic acid transporter activity process transport process organic anion transport process ion transport process anion transport process physiological process process cellular physiological process "
owl:sameAs	drug:L-Methionine
owl:sameAs	drug:L-Serine
rdfs:label	"Glyoxalate, Glyoxylate"
owl:sameAs	drug:L-Glutamic Acid
owl:sameAs	drug:Tetrahydrofolic acid
owl:sameAs	drug:Glyoxalate, Glyoxylate
owl:sameAs	drug:Glycine
owl:sameAs	drug:Zinc
owl:sameAs	drug:2-Oxobutanoic Acid
owl:sameAs	drug:L-Alanine
owl:sameAs	drug:Biotin
owl:sameAs	drug:EXPT01614

" 298-12-4 experimental This compound belongs to the polyamines. These are compounds containing more than one amine group. Polyamines Organic Compounds Organonitrogen Compounds Amines Polyamines Enolates Carboxylic Acids Aldehydes aldehyde logP -0.59 ALOGPS logS 0.48 ALOGPS Water Solubility 2.24e+02 g/l ALOGPS logP -0.13 ChemAxon IUPAC Name 2-oxoacetic acid ChemAxon Traditional IUPAC Name glyoxalate, glyoxylate ChemAxon Molecular Weight 74.0355 ChemAxon Monoisotopic Weight 74.00039393 ChemAxon SMILES OC(=O)C=O ChemAxon Molecular Formula C2H2O3 ChemAxon InChI InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5) ChemAxon InChIKey InChIKey=HHLFWLYXYJOTON-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 54.37 ChemAxon Refractivity 13.5 ChemAxon Polarizability 5.35 ChemAxon Rotatable Bond Count 1 ChemAxon H Bond Acceptor Count 3 ChemAxon H Bond Donor Count 1 ChemAxon pKa (strongest acidic) 2.61 ChemAxon pKa (strongest basic) -9.2 ChemAxon Physiological Charge -1 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Melting Point 98 Â°C PhysProp pKa 3.3 (at 25 Â°C) DEAN,JA (1985) ChEBI 16891 PubChem Compound 760 PubChem Substance 46507705 KEGG Compound C00048 BindingDB 19472 PDB GLV SMP00721 3-Phosphoglycerate dehydrogenase deficiency DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00313 Lactic Acidemia DB00119 Pyruvic acid DB00121 Biotin DB00142 L-Glutamic Acid DB00145 Glycine DB00160 L-Alanine DB00167 L-Isoleucine DB01593 Zinc DB04343 Glyoxalate, Glyoxylate P49588 P24298 P11498 P21549 Q5JTZ9 SMP00055 Alanine Metabolism DB00119 Pyruvic acid DB00121 Biotin DB00142 L-Glutamic Acid DB00145 Glycine DB00160 L-Alanine DB00167 L-Isoleucine DB01593 Zinc DB04343 Glyoxalate, Glyoxylate P49588 P24298 P11498 P21549 Q5JTZ9 SMP00004 Glycine and Serine Metabolism DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00350 Pyruvate Carboxylase Deficiency DB00119 Pyruvic acid DB00121 Biotin DB00142 L-Glutamic Acid DB00145 Glycine DB00160 L-Alanine DB00167 L-Isoleucine DB01593 Zinc DB04343 Glyoxalate, Glyoxylate P49588 P24298 P11498 P21549 Q5JTZ9 SMP00179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00242 Dimethylglycine Dehydrogenase Deficiency DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00484 Dimethylglycinuria DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00223 Non Ketotic Hyperglycinemia DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00485 Hyperglycinemia, non-ketotic DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 SMP00352 Primary Hyperoxaluria Type I DB00119 Pyruvic acid DB00121 Biotin DB00142 L-Glutamic Acid DB00145 Glycine DB00160 L-Alanine DB00167 L-Isoleucine DB01593 Zinc DB04343 Glyoxalate, Glyoxylate P49588 P24298 P11498 P21549 Q5JTZ9 SMP00244 Sarcosinemia DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00119 Pyruvic acid DB00133 L-Serine DB00134 L-Methionine DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB02951 3-Hydroxypyruvic Acid DB02957 Orotidine-5'-Monophosphate DB04343 Glyoxalate, Glyoxylate DB04553 2-Oxobutanoic Acid P21397 P05091 O75600 Q9UI17 Q9UL12 P23378 P48728 P34897 P09622 P21549 P50440 Q14353 P13196 Q93088 Q14749 Q8IVS8 O43175 Q9Y617 P78330 P20132 P49591 P34896 P41250 Q9GZT4 P35520 P32929 BE0001216 Malate synthase G Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Malate synthase G Energy production and conversion Accounts for almost the entire malate-synthesizing activity in cells metabolizing glyoxylate glcB Cytoplasm None 6.09 80490.0 Escherichia coli (strain K12) GenBank Gene Database X74547 GenBank Protein Database 517247 UniProtKB P37330 UniProt Accession MASZ_ECOLI EC 2.3.3.9 MSG >Malate synthase G MSQTITQSRLRIDANFKRFVDEEVLPGTGLDAAAFWRNFDEIVHDLAPENRQLLAERDRI QAALDEWHRSNPGPVKDKAAYKSFLRELGYLVPQPERVTVETTGIDSEITSQAGPQLVVP AMNARYALNAANARWGSLYDALYGSDIIPQEGAMVSGYDPQRGEQVIAWVRRFLDESLPL ENGSYQDVVAFKVVDKQLRIQLKNGKETTLRTPAQFVGYRGDAAAPTCILLKNNGLHIEL QIDANGRIGKDDPAHINDVIVEAAISTILDCEDSVAAVDAEDKILLYRNLLGLMQGTLQE KMEKNGRQIVRKLNDDRHYTAADGSEISLHGRSLLFIRNVGHLMTIPVIWDSEGNEIPEG ILDGVMTGAIALYDLKVQKNSRTGSVYIVKPKMHGPQEVAFANKLFTRIETMLGMAPNTL KMGIMDEERRTSLNLRSCIAQARNRVAFINTGFLDRTGDEMHSVMEAGPMLRKNQMKSTP WIKAYERNNVLSGLFCGLRGKAQIGKGMWAMPDLMADMYSQKGDQLRAGANTAWVPSPTA ATLHALHYHQTNVQSVQANIAQTEFNAEFEPLLDDLLTIPVAENANWSAQEIQQELDNNV QGILGYVVRWVEQGIGCSKVPDIHNVALMEDRATLRISSQHIANWLRHGILTKEQVQASL ENMAKVVDQQNAGDPAYRPMAGNFANSCAFKAASDLIFLGVKQPNGYTEPLLHAWRLREK ESH >2172 bp ATGAGTCAAACCATAACCCAGAGCCGTTTACGCATTGACGCCAATTTTAAACGTTTTGTG GATGAAGAAGTTTTACCGGGAACAGGGCTGGACGCTGCGGCGTTCTGGCGCAATTTTGAT GAGATCGTTCATGATCTGGCACCAGAAAATCGTCAGTTGCTGGCAGAACGCGATCGCATT CAGGCAGCGCTTGATGAGTGGCATCGCAGCAATCCGGGGCCGGTAAAAGATAAAGCGGCC TATAAATCTTTCCTGCGTGAACTGGGCTACCTGGTGCCGCAACCGGAGCGCGTGACGGTG GAAACCACGGGCATTGACAGCGAAATCACCAGCCAGGCGGGGCCGCAGCTGGTGGTTCCG GCAATGAACGCCCGCTACGCGCTGAACGCGGCGAACGCTCGCTGGGGCTCACTGTACGAT GCGTTATACGGCAGCGACATCATCCCGCAGGAAGGGGCGATGGTCAGCGGCTACGATCCG CAACGCGGTGAGCAGGTTATCGCCTGGGTTCGGCGTTTCCTCGATGAATCTCTACCGCTG GAAAACGGCAGCTATCAGGATGTGGTGGCGTTTAAGGTGGTTGATAAACAATTACGCATC CAGTTGAAAAATGGTAAAGAAACCACGTTACGTACTCCAGCACAGTTTGTCGGTTACCGT GGCGATGCCGCTGCGCCGACCTGCATTTTGCTGAAAAATAACGGCCTGCATATTGAGCTG CAAATCGATGCCAATGGGCGGATTGGCAAAGACGATCCGGCGCACATCAACGATGTTATC GTCGAAGCTGCTATCAGTACCATTCTCGACTGCGAAGATTCGGTCGCGGCGGTTGATGCG GAAGATAAAATCCTGCTGTACCGCAACCTGCTGGGCCTGATGCAGGGGACTCTGCAAGAG AAAATGGAGAAAAACGGTCGGCAAATCGTGCGTAAACTGAATGACGATCGTCATTACACC GCCGCCGATGGCTCTGAAATTTCTCTGCACGGACGCTCGCTGCTGTTTATCCGCAACGTG GGTCATTTGATGACCATTCCTGTGATTTGGGACAGCGAAGGCAATGAAATCCCGGAAGGC ATTCTTGATGGCGTCATGACTGGCGCGATTGCCCTCTATGATTTAAAAGTGCAGAAAAAC TCGCGCACTGGCAGCGTCTATATTGTGAAACCGAAAATGCACGGTCCGCAGGAAGTGGCG TTCGCCAACAAACTGTTTACCCGCATTGAGACAATGCTCGGTATGGCACCGAATACCCTG AAAATGGGCATTATGGATGAAGAACGTCGGACCTCGCTGAACTTGCGTAGCTGTATCGCT CAGGCGCGCAACCGCGTGGCGTTCATCAATACCGGTTTCCTCGACCGTACCGGCGATGAA ATGCATTCGGTGATGGAAGCTGGCCCGATGCTGCGTAAAAATCAGATGAAATCGACGCCT TGGATCAAAGCCTACGAGCGTAATAACGTGCTTTCCGGTCTGTTCTGTGGGCTGCGCGGT AAAGCGCAAATTGGTAAAGGCATGTGGGCAATGCCGGACCTGATGGCAGACATGTACAGC CAGAAGGGCGACCAACTGCGTGCCGGGGCAAACACAGCCTGGGTTCCGTCACCAACCGCT GCTACGCTCCATGCGCTGCACTACCACCAAACCAACGTACAGAGCGTACAAGCCAACATT GCCCAGACCGAGTTCAATGCTGAATTTGAACCGCTGCTGGACGATCTGCTGACTATTCCG GTTGCTGAAAACGCTAACTGGTCGGCGCAAGAGATCCAACAAGAGCTGGATAACAACGTG CAGGGGATTCTGGGGTACGTGGTGCGCTGGGTGGAGCAGGGGATTGGTTGTTCAAAAGTG CCGGATATTCACAATGTGGCGTTGATGGAAGACCGCGCAACGCTGCGTATCTCCAGCCAG CATATCGCCAACTGGTTACGTCACGGTATTCTGACCAAAGAACAGGTGCAGGCGTCGCTG GAGAATATGGCGAAAGTGGTTGATCAGCAAAACGCTGGCGATCCGGCTTATCGTCCGATG GCGGGGAATTTCGCTAACTCGTGTGCTTTTAAAGCTGCCAGCGATTTAATCTTCCTCGGC GTGAAACAGCCAAACGGCTATACCGAACCGTTATTACACGCCTGGCGTTTACGCGAAAAA GAAAGTCATTAA PF01274 Malate_synthase function transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer function malate synthase activity function catalytic activity function transferase activity function transferase activity, transferring acyl groups process physiological process process glyoxylate cycle process metabolism process cellular metabolism process generation of precursor metabolites and energy process energy derivation by oxidation of organic compounds process main pathways of carbohydrate metabolism process tricarboxylic acid cycle BE0001761 Isocitrate lyase Mycobacterium tuberculosis # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Isocitrate lyase Energy production and conversion Isocitrate = succinate + glyoxylate icl Cytoplasm None 4.79 47087.0 Mycobacterium tuberculosis GenBank Gene Database BX842573 GenBank Protein Database 38490185 UniProtKB P0A5H3 UniProt Accession ACEA_MYCTU EC 4.1.3.1 ICL Isocitrase Isocitratase >Isocitrate lyase MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQL HDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQV VRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSH WEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSD VDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEA VKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFD LAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTG STEEGQFH >1287 bp ATGTCTGTCGTCGGCACCCCGAAGAGCGCGGAGCAGATCCAGCAGGAATGGGACACGAAC CCGCGCTGGAAGGACGTCACCCGCACCTACTCCGCCGAGGACGTCGTCGCCCTCCAGGGC AGCGTGGTCGAGGAGCACACGCTGGCCCGCCGCGGTGCGGAGGTGCTGTGGGAGCAGCTG CACGACCTCGAGTGGGTCAACGCGCTGGGCGCGCTGACCGGCAACATGGCCGTCCAGCAG GTGCGCGCCGGCCTGAAGGCCATCTACCTGTCGGGCTGGCAGGTCGCCGGCGATGCCAAC CTGTCCGGGCACACCTACCCCGACCAGAGCCTGTATCCCGCCAACTCGGTGCCGCAGGTG GTCCGCCGGATCAACAACGCACTGCAGCGCGCCGACCAGATCGCCAAGATCGAGGGCGAT ACTTCGGTGGAGAACTGGCTGGCGCCGATTGTCGCCGACGGCGAGGCCGGCTTTGGCGGC GCGCTCAACGTCTACGAGCTGCAGAAAGCCCTGATCGCCGCGGGCGTTGCGGGTTCGCAC TGGGAGGACCAGTTGGCCTCTGAGAAGAAGTGCGGCCACCTGGGCGGCAAGGTGTTGATC CCGACCCAGCAGCACATCCGCACTTTGACGTCTGCTCGGCTCGCGGCCGATGTGGCTGAT GTTCCCACGGTGGTGATCGCCCGTACCGACGCCGAGGCGGCCACGCTGATCACCTCCGAC GTCGACGAGCGCGACCAGCCGTTCATCACCGGCGAGCGCACCCGGGAAGGCTTCTACCGC ACCAAGAACGGCATCGAGCCTTGCATCGCTCGGGCGAAGGCCTACGCCCCGTTCGCCGAC TTGATCTGGATGGAGACCGGTACCCCGGACCTCGAGGCCGCCCGGCAGTTCTCCGAGGCG GTCAAGGCGGAGTACCCGGACCAGATGCTGGCCTACAACTGCTCGCCATCGTTCAACTGG AAAAAGCACCTCGACGACGCCACCATCGCCAAGTTCCAGAAGGAGCTGGCAGCCATGGGC TTCAAGTTCCAGTTCATCACGCTGGCCGGCTTCCATGCGCTGAACTACTCGATGTTCGAT CTGGCCTACGGCTACGCCCAGAACCAGATGAGCGCGTATGTCGAACTGCAGGAACGCGAG TTCGCCGCCGAAGAACGGGGCTACACCGCGACCAAGCACCAGCGCGAGGTCGGCGCCGGC TACTTCGACCGGATTGCCACCACCGTGGACCCGAATTCGTCGACCACCGCGTTGACCGGT TCCACCGAAGAGGGCCAGTTCCACTAG PF00463 ICL function carbon-carbon lyase activity function oxo-acid-lyase activity function isocitrate lyase activity function catalytic activity function lyase activity process generation of precursor metabolites and energy process energy derivation by oxidation of organic compounds process main pathways of carbohydrate metabolism process glyoxylate cycle process physiological process process metabolism process cellular metabolism BE0001750 Malate synthase G Mycobacterium tuberculosis # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Malate synthase G Energy production and conversion Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA glcB Cytoplasm None 4.83 80404.0 Mycobacterium tuberculosis GenBank Gene Database BX842578 GenBank Protein Database 1483534 UniProtKB P0A5J4 UniProt Accession MASZ_MYCTU EC 2.3.3.9 >Malate synthase G MTDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVADLTPQNQALLNARDEL QAQIDKWHRRRVIEPIDMDAYRQFLTEIGYLLPEPDDFTITTSGVDAEITTTAGPQLVVP VLNARFALNAANARWGSLYDALYGTDVIPETDGAEKGPTYNKVRGDKVIAYARKFLDDSV PLSSGSFGDATGFTVQDGQLVVALPDKSTGLANPGQFAGYTGAAESPTSVLLINHGLHIE ILIDPESQVGTTDRAGVKDVILESAITTIMDFEDSVAAVDAADKVLGYRNWLGLNKGDLA AAVDKDGTAFLRVLNRDRNYTAPGGGQFTLPGRSLMFVRNVGHLMTNDAIVDTDGSEVFE GIMDALFTGLIAIHGLKASDVNGPLINSRTGSIYIVKPKMHGPAEVAFTCELFSRVEDVL GLPQNTMKIGIMDEERRTTVNLKACIKAAADRVVFINTGFLDRTGDEIHTSMEAGPMVRK GTMKSQPWILAYEDHNVDAGLAAGFSGRAQVGKGMWTMTELMADMVETKIAQPRAGASTA WVPSPTAATLHALHYHQVDVAAVQQGLAGKRRATIEQLLTIPLAKELAWAPDEIREEVDN NCQSILGYVVRWVDQGVGCSKVPDIHDVALMEDRATLRISSQLLANWLRHGVITSADVRA SLERMAPLVDRQNAGDVAYRPMAPNFDDSIAFLAAQELILSGAQQPNGYTEPILHRRRRE FKARAAEKPAPSDRAGDDAAR >2226 bp CTAGCGGGCCGCATCGTCACCGGCCCTGTCCGATGGGGCCGGCTTCTCAGCGGCCCGGGC CTTAAACTCCCGACGACGTCGGTGCAGGATCGGCTCGGTGTAGCCGTTGGGCTGCTGGGC CCCGGACAAGATCAGCTCCTGCGCGGCCAGGAAGGCGATACTGTCGTCGAAGTTGGGTGC CATCGGTCGGTATGCCACGTCGCCCGCGTTTTGTCGATCGACCAACGGCGCCATCCGCTC CAAGCTGGCCCGCACATCCGCGCTGGTGATCACACCGTGGCGCAGCCAGTTGGCCAACAA TTGGCTGGAGATTCGCAGCGTGGCCCGGTCCTCCATGAGCGCGACGTCGTGGATGTCGGG CACCTTCGAGCAGCCGACACCTTGATCAACCCAGCGAACCACGTAGCCGAGGATGGATTG ACAGTTGTTGTCGACCTCTTCGCGGATCTCGTCGGGAGCCCAGGCCAATTCCTTGGCCAG CGGAATGGTCAGCAATTGTTCGATGGTGGCGCGACGCTTCCCCGCCAGTCCTTGTTGCAC CGCGGCGACGTCGACCTGGTGGTAGTGCAGCGCATGCAGGGTGGCCGCAGTGGGAGAGGG AACCCAGGCGGTGCTGGCCCCGGCGCGCGGCTGGGCGATTTTTGTCTCGACCATGTCGGC CATCAGCTCGGTCATTGTCCACATGCCCTTGCCGACCTGGGCTCGGCCGCTGAACCCGGC GGCCAGGCCGGCATCGACGTTGTGGTCCTCGTAGGCCAAGATCCACGGCTGGCTCTTCAT GGTGCCCTTGCGCACCATCGGGCCGGCCTCCATCGAGGTGTGGATTTCATCGCCGGTGCG GTCCAGGAACCCGGTGTTGATGAACACCACGCGGTCCGCGGCAGCTTTGATGCACGCCTT GAGGTTGACCGTGGTCCGGCGTTCCTCGTCCATGATGCCGATCTTCATGGTGTTTTGCGG CAACCCCAGCACATCTTCAACCCGGCTGAACAGTTCGCAGGTAAACGCCACCTCGGCCGG ACCGTGCATCTTCGGCTTGACGATGTAGATGGAGCCGGTGCGGCTGTTGATCAGCGGCCC GTTGACGTCGCTGGCCTTTAGCCCGTGGATGGCGATCAGGCCGGTGAATAGGGCATCCAT GATGCCTTCGAACACCTCGCTGCCGTCAGTGTCGACGATGGCGTCATTCGTCATCAAGTG ACCGACGTTGCGGACGAACATGAGGCTGCGTCCAGGCAGCGTGAACTGGCCACCGCCGGG TGCGGTGTAGTTCCGGTCCCTATTGAGCACCCGCAGGAAAGCGGTGCCGTCCTTGTCTAC CGCTGCTGCCAGGTCGCCCTTGTTCAGGCCGAGCCAGTTCCGATAACCCAGCACCTTGTC GGCGGCGTCCACGGCGGCCACCGAGTCCTCGAAGTCCATGATCGTGGTGATCGCGGATTC CAGGATCACGTCCTTGACGCCGGCCCGGTCGGTGGTGCCGACCTGCGACTCCGGATCGAT CAGGATCTCGATGTGCAAACCGTGATTGATTAGCAGCACCGATGTCGGCGACTCGGCTGC GCCGGTGTAGCCGGCGAACTGGCCGGGGTTGGCCAGGCCGGTGGACTTATCCGGCAAGGC AACCACGAGCTGGCCATCCTGCACTGTGAAACCGGTGGCGTCGCCAAAGGAACCCGACGA CAGCGGAACACTGTCGTCGAGGAACTTGCGGGCATACGCGATCACCTTGTCGCCACGAAC CTTGTTGTACGTGGGGCCTTTTTCGGCGCCGTCGGTCTCGGGGATGACATCGGTGCCATA CAAGGCGTCGTAGAGGGAGCCCCAGCGAGCGTTGGCCGCGTTCAGAGCAAACCGCGCGTT GAGCACCGGCACCACCAGCTGGGGGCCGGCGGTCGTGGTGATCTCAGCGTCGACACCGGA CGTGGTGATGGTGAAGTCATCAGGTTCGGGAAGCAGGTAGCCGATCTCGGTGAGGAACTG GCGGTAGGCATCCATGTCGATGGGCTCGATCACCCGACGCCGGTGCCACTTGTCGATCTG CGCCTGCAGCTCGTCGCGGGCGTTCAACAGAGCTTGGTTCTGCGGGGTCAGGTCGGCGAC GACCTTGTCGACGCCCGCCCAGAAGCTGTCCGGGTCGATATCGGTGCCAGGCAGGGCTTC ATTGTTCACGAAGTCGTAGAGCACCCGAGCGATGCGCAAGTTGCCCACCGACACGCGATC TGTCAT PF01274 Malate_synthase function transferase activity function transferase activity, transferring acyl groups function transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer function malate synthase activity function catalytic activity process metabolism process cellular metabolism process generation of precursor metabolites and energy process energy derivation by oxidation of organic compounds process main pathways of carbohydrate metabolism process tricarboxylic acid cycle process physiological process process glyoxylate cycle BE0001689 Putative regulator of ribonuclease activity Mycobacterium tuberculosis # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Putative regulator of ribonuclease activity Coenzyme transport and metabolism Regulator of RNase E/rne, which inhibits the endonuclease activity and thereby leads to increase the half-life and abundance of RNAs. General modulator of RNA abundance. Does not have any methyltransferase activity Rv3853 None 4.84 16236.0 Mycobacterium tuberculosis GenBank Gene Database BX842584 GenBank Protein Database 1781103 UniProtKB P0A666 UniProt Accession RRAAH_MYCTU >Regulator of ribonuclease activity A MAISFRPTADLVDDIGPDVRSCDLQFRQFGGRSQFAGPISTVRCFQDNALLKSVLSQPSA GGVLVIDGAGSLHTALVGDVIAELARSTGWTGLIVHGAVRDAAALRGIDIGIKALGTNPR KSTKTGAGERDVEITLGGVTFVPGDIAYSDDDGIIVV >474 bp GTGGCCATCTCATTTCGCCCAACCGCTGACCTCGTCGACGACATCGGGCCCGACGTGCGC AGCTGTGACCTACAGTTCCGCCAATTCGGCGGCCGATCGCAGTTCGCCGGACCGATCAGC ACCGTGCGGTGTTTTCAGGACAATGCGTTGCTGAAGTCGGTGCTCTCGCAGCCAAGTGCG GGCGGTGTGCTGGTCATCGACGGCGCCGGGTCCCTGCACACCGCGTTGGTCGGTGATGTC ATCGCCGAGTTGGCCCGCTCTACCGGCTGGACCGGGTTGATCGTCCACGGCGCGGTGCGA GATGCCGCCGCGCTGCGCGGCATCGACATCGGCATCAAAGCGCTGGGCACCAATCCCCGC AAGAGCACCAAGACCGGTGCCGGAGAACGCGACGTTGAAATCACGCTGGGCGGGGTGACA TTCGTTCCGGGCGATATCGCCTACAGCGACGACGACGGCATCATCGTCGTCTGA PF03737 Methyltransf_6 BE0000449 Monocarboxylate transporter 4 Human substrate # Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11101640 unknown Monocarboxylate transporter 4 Carbohydrate transport and metabolism Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate SLC16A3 17q25 Cell membrane; multi-pass membrane protein 18-38 62-82 85-105 110-130 150-170 180-200 228-248 265-285 295-315 318-338 352-372 385-405 8.03 49470.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:10924 GenAtlas SLC16A3 GeneCards SLC16A3 GenBank Gene Database U81800 GenBank Protein Database 2463634 UniProtKB O15427 UniProt Accession MOT4_HUMAN MCT 3 MCT 4 Solute carrier family 16 member 3 >Monocarboxylate transporter 4 MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV >1398 bp ATGGGAGGGGCCGTGGTGGACGAGGGCCCCACAGGCGTCAAGGCCCCTGACGGCGGCTGG GGCTGGGCCGTGCTCTTCGGCTGTTTCGTCATCACTGGCTTCTCCTACGCCTTCCCCAAG GCCGTCAGTGTCTTCTTCAAGGAGCTCATACAGGAGTTTGGGATCGGCTACAGCGACACA GCCTGGATCTCCTCCATCCTGCTGGCCATGCTCTACGGGACAGGTCCGCTCTGCAGTGTG TGCGTGAACCGCTTTGGCTGCCGGCCCGTCATGCTTGTGGGGGGTCTCTTTGCGTCGCTG GGCATGGTGGCTGCGTCCTTTTGCCGGAGCATCATCCAGGTCTACCTCACCACTGGGGTC ATCACGGGGTTGGGTTTGGCACTCAACTTCCAGCCCTCGCTCATCATGCTGAACCGCTAC TTCAGCAAGCGGCGCCCCATGGCCAACGGGCTGGCGGCAGCAGGTAGCCCTGTCTTCCTG TGTGCCCTGAGCCCGCTGGGGCAGCTGCTGCAGGACCGCTACGGCTGGCGGGGCGGCTTC CTCATCCTGGGCGGCCTGCTGCTCAACTGCTGCGTGTGTGCCGCACTCATGAGGCCCCTG GTGGTCACGGCCCAGCCGGGCTCGGGGCCGCCGCGACCCTCCCGGCGCCTGCTAGACCTG AGCGTCTTCCGGGACCGCGGCTTTGTGCTTTACGCCGTGGCCGCCTCGGTCATGGTGCTG GGGCTCTTCGTCCCGCCCGTGTTCGTGGTGAGCTACGCCAAGGACCTGGGCGTGCCCGAC ACCAAGGCCGCCTTCCTGCTCACCATCCTGGGCTTCATTGACATCTTCGCGCGGCCGGCC GCGGGCTTCGTGGCGGGGCTTGGGAAGGTGCGGCCCTACTCCGTCTACCTCTTCAGCTTC TCCATGTTCTTCAACGGCCTCGCGGACCTGGCGGGCTCTACGGCGGGCGACTACGGCGGC CTCGTGGTCTTCTGCATCTTCTTTGGCATCTCCTACGGCATGGTGGGGGCCCTGCAGTTC GAGGTGCTCATGGCCATCGTGGGCACCCACAAGTTCTCCAGTGCCATTGGCCTGGTGCTG CTGATGGAGGCGGTGGCCGTGCTCGTCGGGCCCCCTTCGGGAGGCAAACTCCTGGATGCG ACCCACGTCTACATGTACGTGTTCATCCTGGCGGGGGCCGAGGTGCTCACCTCCTCCCTG ATTTTGCTGCTGGGCAACTTCTTCTGCATTAGGAAGAAGCCCAAAGAGCCACAGCCTGAG GTGGCGGCCGCGGAGGAGGAGAAGCTCCACAAGCCTCCTGCAGACTCGGGGGTGGACTTG CGGGAGGTGGAGCATTTCCTGAAGGCTGAGCCTGAGAAAAACGGGGAGGTGGTTCACACC CCGGAAACAAGTGTCTGA PF07690 MFS_1 component cell component intrinsic to membrane component integral to membrane component membrane function monocarboxylic acid transporter activity function transporter activity function monocarboxylate porter activity function organic acid transporter activity function carboxylic acid transporter activity process transport process organic anion transport process ion transport process anion transport process physiological process process cellular physiological process "

owl:sameAs

drug:L-Serine

owl:sameAs

drug:L-Glutamic Acid

owl:sameAs

drug:Glyoxalate, Glyoxylate

Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB04343"

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