Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB06168"

Predicate	Value (sorted: none)
owl:sameAs	drug:Natalizumab
drugbank:description	"Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. Both heavy chains of canakinumab contain oligosaccharide chains linked to the protein backbone at asparagine 298 (Asn 298). Canakinumab binds to human IL-1β and neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors, but it does not bind IL-1alpha or IL-1 receptor antagonist (IL-1ra). Canakinumab is marketed under the brand name Ilaris and indicated for patients 4 years of age and older to treat Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS), which are both part of the Cryopyrin-Associated Periodic Syndromes (CAPS) as well as for patients 2 years of age and older to treat systemic juvenile idiopathic arthritis (SJIA). Clinical trials have established the administration of canakinumab every 2 weeks to be safe and effective, offering a considerable advantage over the existing treatment with the human IL-1 receptor antagonist, anakinra, which must be injected daily and which is often poorly tolerated by patients."
rdf:type	drugbank:drugs
drugbank:interactsWith	drug:Basiliximab
drugbank:interactsWith	drug:Rilonacept
drugbank:drugCategory	drugcategory:Monoclonal antibodies
owl:sameAs	drug:Basiliximab
drugbank:interactsWith	drug:Pimecrolimus
drugbank:interactsWith	drug:Anakinra
owl:sameAs	drug:Rilonacept
owl:sameAs	drug:Anakinra
owl:sameAs	drug:golimumab
owl:sameAs	drug:Pimecrolimus
drugbank:interactsWith	drug:Adalimumab
drugbank:interactsWith	drug:golimumab
drugbank:drugCategory	drugcategory:Anti-Inflammatory Agents
owl:sameAs	drug:Antithymocyte globulin
drugbank:interactsWith	drug:Antithymocyte globulin
drugbank:interactsWith	drug:Tofacitinib
drugbank:interactsWith	drug:Azathioprine
drugbank:interactsWith	drug:Natalizumab
owl:sameAs	drug:Adalimumab
owl:sameAs	drug:Alefacept
owl:sameAs	drug:Tofacitinib
rdfs:label	"Canakinumab"
drugbank:interactsWith	drug:Alefacept
owl:sameAs	drug:Azathioprine

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines2/drugbank_small.nt

The resource appears as object in 22 triples

Context graph