Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB06414"

Predicate	Value (sorted: default)
rdfs:label	"Etravirine"
rdf:type	drugbank:drugs
drugbank:description	"Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor(NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 100mg tablets in the treatment of adult HIV-1 infection documented to be resistant to therapy with other NNRTIs and antiretroviral agents. On March 26, 2012, approval was extended for use in treatment-experienced pediatric patients 6 to 18 years of age, weighing at least 16 kg. Etravarine must always be used in combination with other antiretroviral drugs. Etravirine exerts its effects via direct inhibition of the reverse transcriptase enzyme of human immunodeficiency virus type 1 (HIV-1), and consequently blocks DNA-dependent and RNA-dependent polymerase activity. Etravirine does not inhibit human DNA polymerase alpha, beta or gamma. Common side effects of use include mild to moderate rash within the first 6 weeks of therapy, nausea, diarrhea and peripheral neuropathy. Patients are advised to immediately contact their healthcare provider if a rash develops. In 2009, postmarketing case reports of Stevens-Johnson Syndrome, toxic epidermal necrolysis, erythema multiforme, and other hypersensitivity reactions lead to a revision of etravirine's "Warnings and Precautions," as well as notification of health care providers. In 2013, reports of Autoimmune disorders (such as Graves’ disease, polymyositis, and Guillain-Barré syndrome) in the setting of immune reconstitution, as well as more in depth information about the development of rashes in patients taking etravirine, lead to a modification of etravirine's monograph. "
drugbank:drugCategory	drugcategory:Reverse Transcriptase Inhibitors
drugbank:interactsWith	drug:Peginterferon alfa-2a drug:Bortezomib drug:Tramadol drug:Sildenafil drug:Citalopram drug:Lovastatin drug:Nevirapine drug:Phenytoin drug:Disopyramide drug:Lidocaine drug:Gefitinib drug:Methadone drug:Mexiletine drug:Digoxin drug:Sorafenib drug:Nisoldipine drug:Toremifene drug:Vincristine drug:Carbamazepine drug:Voriconazole drug:Rifabutin drug:Imatinib drug:Efavirenz drug:Simvastatin drug:Trazodone drug:Delavirdine drug:Tamsulosin drug:Clopidogrel drug:Primidone drug:Diazepam drug:Mifepristone drug:Quinidine drug:Buprenorphine drug:Tipranavir drug:Exemestane drug:Guanfacine drug:Ketoconazole drug:Tolterodine drug:Praziquantel drug:Atazanavir drug:Atorvastatin drug:Fluvastatin drug:Nifedipine drug:Amiodarone drug:Carvedilol drug:Phenobarbital drug:Ifosfamide drug:Propafenone drug:Flecainide drug:Clarithromycin drug:Quetiapine drug:Paclitaxel drug:Saquinavir drug:Aripiprazole drug:Bepridil drug:Dasatinib drug:Lapatinib drug:Darunavir drug:Fosamprenavir drug:Fosphenytoin drug:St. John's Wort drug:Everolimus drug:Lopinavir drug:Deferasirox drug:Zuclopenthixol drug:Roflumilast drug:Rifamycin Cgp 4832 drug:Maraviroc drug:Dronedarone drug:Nilotinib drug:Vandetanib drug:Telaprevir drug:DB06176 drug:Tolvaptan drug:Rivaroxaban drug:Pazopanib drug:Apixaban drug:Bosutinib drug:Axitinib drug:Artemether drug:Lurasidone drug:Ticagrelor drug:Ivacaftor drug:Rilpivirine drug:Crizotinib drug:Brentuximab vedotin drug:Boceprevir drug:Cabozantinib drug:Linagliptin drug:Perampanel drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate
owl:sameAs	drug:Peginterferon alfa-2a drug:Bortezomib drug:Tramadol drug:Sildenafil drug:Citalopram drug:Lovastatin drug:Nevirapine drug:Phenytoin drug:Disopyramide drug:Lidocaine drug:Gefitinib drug:Methadone drug:Mexiletine drug:Digoxin drug:Sorafenib drug:Nisoldipine drug:Toremifene drug:Vincristine drug:Carbamazepine drug:Voriconazole drug:Rifabutin drug:Imatinib drug:Efavirenz drug:Simvastatin drug:Trazodone drug:Delavirdine drug:Tamsulosin drug:Clopidogrel drug:Primidone drug:Diazepam drug:Mifepristone drug:Quinidine drug:Buprenorphine drug:Tipranavir drug:Exemestane drug:Guanfacine drug:Ketoconazole drug:Tolterodine drug:Praziquantel drug:Atazanavir drug:Atorvastatin drug:Fluvastatin drug:Nifedipine drug:Amiodarone drug:Carvedilol drug:Phenobarbital drug:Ifosfamide drug:Propafenone drug:Flecainide drug:Clarithromycin drug:Quetiapine drug:Paclitaxel drug:Saquinavir drug:Aripiprazole drug:Bepridil drug:Dasatinib drug:Lapatinib drug:Darunavir drug:Fosamprenavir drug:Fosphenytoin drug:St. John's Wort drug:Everolimus drug:Lopinavir drug:Deferasirox drug:Zuclopenthixol drug:Roflumilast drug:Rifamycin Cgp 4832 drug:Maraviroc drug:Dronedarone drug:Nilotinib drug:Vandetanib drug:Telaprevir drug:DB06176 drug:Tolvaptan drug:Rivaroxaban drug:Pazopanib drug:Apixaban drug:Bosutinib drug:Axitinib drug:Artemether drug:Lurasidone drug:Ticagrelor drug:Ivacaftor drug:Rilpivirine drug:Crizotinib drug:Brentuximab vedotin drug:Boceprevir drug:Cabozantinib drug:Linagliptin drug:Perampanel drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate

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The resource appears as object in 183 triples

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